Document Detail


Association of TNFSF15 with Crohn's disease in Koreans.
MedLine Citation:
PMID:  18422820     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: A recent genomewide association study from a Japanese population identified tumor necrosis factor superfamily member 15 (TNFSF15) as an inflammatory bowel disease gene. Previous studies have shown that expression of TNFSF15 was upregulated in macrophages and lymphocytes of the intestinal lamina propria of Crohn's disease (CD) patients. Here, we have tested four single nucleotide polymorphisms (SNPs) of TNFSF15 in Korean patients to determine whether the gene is associated with susceptibility to CD in a closely related population. METHODS: Four SNPs across TNFSF15 were genotyped in 380 patients with CD and 380 healthy controls. RESULTS: Carriers of three polymorphisms, including rs3810936, rs6478108, and rs7848647, showed statistically significant association with CD (adjusted OR [aOR] 2.81, 95% confidence interval [CI] 1.94-4.07, P= 4.4 x 10(-8); aOR 3.49, 95% CI 2.42-5.04, P= 2.7 x 10(-11); and aOR 3.49, 95% CI 2.42-5.03, P= 2.2 x 10(-11), respectively). Following haplotype analysis, homozygotes carrying two copies of the haplotype consisting of the risk alleles of those three SNPs showed statistically significant association with CD (aOR 5.39, 95% CI 3.19-9.10, P= 3.07 x 10(-10)). CONCLUSIONS: Our data support the hypothesis that the TNFSF15 genotypes play an important role in the pathogenesis of CD in Koreans.
Authors:
Suk-Kyun Yang; Jiyoung Lim; Hye-Sook Chang; Inchul Lee; Yuqing Li; Jianjun Liu; Kyuyoung Song
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-04-16
Journal Detail:
Title:  The American journal of gastroenterology     Volume:  103     ISSN:  1572-0241     ISO Abbreviation:  Am. J. Gastroenterol.     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-06-12     Completed Date:  2008-07-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0421030     Medline TA:  Am J Gastroenterol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1437-42     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
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MeSH Terms
Descriptor/Qualifier:
Adult
Asian Continental Ancestry Group / genetics*
Case-Control Studies
Cohort Studies
Crohn Disease / ethnology*,  genetics*,  pathology
Female
Genetic Predisposition to Disease / ethnology,  genetics
Genotype
Haplotypes
Humans
Korea
Male
Middle Aged
Phenotype
Polymorphism, Single Nucleotide / genetics*
Tumor Necrosis Factor Ligand Superfamily Member 15 / genetics*
Chemical
Reg. No./Substance:
0/TNFSF15 protein, human; 0/Tumor Necrosis Factor Ligand Superfamily Member 15

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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