Document Detail

Association of TMEM18 variants with BMI and waist circumference in children and correlation of mRNA expression in the PFC with body weight in rats.
MedLine Citation:
PMID:  21952719     Owner:  NLM     Status:  MEDLINE    
Genome-wide association studies have shown a strong association of single-nucleotide polymorphisms (SNPs) in the near vicinity of the TMEM18 gene. The effects of the TMEM18-associated variants are more readily observed in children. TMEM18 encodes a 3TM protein, which locates to the nuclear membrane. The functional context of TMEM18 and the effects of its associated variants are as of yet undetermined. To further explore the effects of near-TMEM18 variants, we have genotyped two TMEM18-associated SNPs, rs6548238 and rs4854344, in a cohort of 2352 Greek children (Healthy Growth Study). Included in this study are data on anthropomorphic traits body weight, BMI z-score and waist circumference. Also included are dietary energy and macronutrient intake as measured via 24-h recall interviews. Major alleles of rs6548238 and rs4854344 were significantly associated with an increased risk of obesity (odds ratio = 1.489 (1.161-1.910) and 1.494 (1.165-1.917), respectively), and positively correlated to body weight (P = 0.017, P = 0.010) and waist circumference (P = 0.003, P = 0.003). An association to energy and macronutrient intake was not observed in this cohort. We also correlated food intake and body weight in a food choice model in rats to Tmem18 expression in central regions involved in feeding behavior. We observed a strong positive correlation between TMEM18 expression and body weight in the prefrontal cortex (PFC) (r = 0.5694, P = 0.0003) indicating a potential role for TMEM18 in higher functions related to feeding involving the PFC.
Mathias Rask-Andersen; Josefin A Jacobsson; George Moschonis; Rohit A Chavan; Md Abu Noman Sikder; Elin Allzén; Johan Alsiö; George P Chrousos; Yannis Manios; Robert Fredriksson; Helgi B Schiöth
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-09-28
Journal Detail:
Title:  European journal of human genetics : EJHG     Volume:  20     ISSN:  1476-5438     ISO Abbreviation:  Eur. J. Hum. Genet.     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-01-12     Completed Date:  2012-05-07     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  9302235     Medline TA:  Eur J Hum Genet     Country:  England    
Other Details:
Languages:  eng     Pagination:  192-7     Citation Subset:  IM    
Department of Neuroscience, Functional Pharmacology, Uppsala University, BMC, Uppsala, Sweden.
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MeSH Terms
Body Mass Index*
Body Weight / genetics*
Genetic Association Studies
Membrane Proteins / genetics*
Obesity / genetics
Polymorphism, Single Nucleotide*
Prefrontal Cortex / metabolism*
RNA, Messenger / genetics*
Rats, Wistar
Waist Circumference / genetics*
Reg. No./Substance:
0/Membrane Proteins; 0/RNA, Messenger; 0/TMEM18 protein, human

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