Document Detail


Association of TIMP-2 with extracellular matrix exposed to mechanical stress and its co-distribution with periostin during mouse mandible development.
MedLine Citation:
PMID:  17602244     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Matrix remodeling is regulated by matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs). Periostin, originally identified in a mouse osteoblastic library, plays a role in cell adhesion and migration and in mechanical stress-induced matrix remodeling. In this study, we analyzed and compared the distribution patterns of TIMP-2 and periostin during mouse mandible development. Immunohistochemical staining for TIMP-2 and periostin was carried out on serial cryosections obtained from mice at embryonic days 13-16, postnatal day 2 (P2), P35, and 12 weeks of age. TIMP-2 and periostin exhibited a strikingly similar protein distribution during mandible development. From bud to early bell stages of molars, TIMP-2 and periostin were highly expressed on the lingual and anterior sides of the basement membrane and on the adjacent jaw mesenchyme. In pre- and postnatal incisors, the basement membrane of the apical loop and dental follicle was immunostained for TIMP-2 and periostin. At postnatal stages, TIMP-2 and periostin were prominently confined to the extracellular matrix (ECM) of gingival tissues, periodontal ligaments, and tendons (all recipients of mechanical strain). However, periostin was solely detected in the lower portion of the inner root sheath of hair follicles. Gingiva of P2 cultured in anti-TIMP-2 antibody-conditioned medium showed markedly reduced staining of periostin. We suggest that TIMP-2 and periostin are co-distributed on ECM exposed to mechanical forces and coordinately function as ECM modulators.
Authors:
Nagako Yoshiba; Kunihiko Yoshiba; Akihiro Hosoya; Masahiro Saito; Takamasa Yokoi; Takashi Okiji; Norio Amizuka; Hidehiro Ozawa
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-06-30
Journal Detail:
Title:  Cell and tissue research     Volume:  330     ISSN:  0302-766X     ISO Abbreviation:  Cell Tissue Res.     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-09-19     Completed Date:  2008-02-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0417625     Medline TA:  Cell Tissue Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  133-45     Citation Subset:  IM    
Affiliation:
Division of Cariology, Operative Dentistry and Endodontics, Department of Oral Health Science, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan. nagako@dent.niigata-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn
Cell Adhesion Molecules / physiology*
Cells, Cultured
Embryonic Development
Extracellular Matrix / physiology*
Gingiva / cytology,  growth & development,  physiology
Immunohistochemistry
Mandible / cytology,  embryology*,  growth & development
Mice
Stress, Mechanical
Tissue Inhibitor of Metalloproteinase-3 / physiology*
Chemical
Reg. No./Substance:
0/Cell Adhesion Molecules; 0/Postn protein, mouse; 0/Tissue Inhibitor of Metalloproteinase-3

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