| Association of TGFBR2 polymorphism with risk of sudden cardiac arrest in patients with coronary artery disease. | |
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MedLine Citation:
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PMID: 19959123 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Transforming growth factor ss (TGFss) signaling has been shown to promote myocardial fibrosis and remodeling with coronary artery disease (CAD), and previous studies show a major role for fibrosis in the initiation of malignant ventricular arrhythmias (VA) and sudden cardiac arrest (SCA). Common single nucleotide polymorphisms (SNPs) in TGFss pathway genes may be associated with SCA. OBJECTIVE: We examined the association of common SNPs among 12 candidate genes in the TGFss pathway with the risk of SCA. METHODS: SNPs (n = 617) were genotyped in a case-control study comparing 89 patients with CAD and SCA caused by VA to 520 healthy control subjects. RESULTS: Nineteen SNPs among 5 genes (TGFB2, TGFBR2, SMAD1, SMAD3, SMAD6) were associated with SCA after adjustment for age and sex. After permutation analysis to account for multiple testing, a single SNP in TGFBR2 (rs9838682) was associated with SCA (odds ratio: 1.66, 95% confidence interval: 1.08 to 2.54, P = .02). CONCLUSION: We show an association between a common TGFBR2 polymorphism and risk of SCA caused by VA in the setting of CAD. If validated, these findings support the role of genetic variation in TGFss signaling in SCA susceptibility. |
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Authors:
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Zian H Tseng; Eric Vittinghoff; Stacy L Musone; Feng Lin; Dean Whiteman; Ludmila Pawlikowska; Pui-Yan Kwok; Jeffrey E Olgin; Bradley E Aouizerat |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2009-08-28 |
Journal Detail:
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Title: Heart rhythm : the official journal of the Heart Rhythm Society Volume: 6 ISSN: 1556-3871 ISO Abbreviation: Heart Rhythm Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-12-04 Completed Date: 2011-01-28 Revised Date: 2013-03-22 |
Medline Journal Info:
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Nlm Unique ID: 101200317 Medline TA: Heart Rhythm Country: United States |
Other Details:
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Languages: eng Pagination: 1745-50 Citation Subset: IM |
Affiliation:
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Section of Cardiac Electrophysiology, Division of Cardiology, Department of Medicine, University of California, San Francisco, California 94143-1354, USA. zhtseng@medicine.ucsf.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged California / epidemiology Case-Control Studies Confidence Intervals Coronary Artery Disease / complications, epidemiology, genetics* Death, Sudden, Cardiac / epidemiology*, etiology, pathology Female Humans Male Odds Ratio Polymorphism, Single Nucleotide* Protein-Serine-Threonine Kinases / genetics* Receptors, Transforming Growth Factor beta / genetics* Risk Assessment Risk Factors Signal Transduction Tachycardia, Ventricular / genetics Tumor Necrosis Factor-alpha United States / epidemiology Ventricular Fibrillation / epidemiology, genetics |
| Grant Support | |
ID/Acronym/Agency:
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KL2 RR024130/RR/NCRR NIH HHS; KL2 RR024130/RR/NCRR NIH HHS; KL2 RR024130-03/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Transforming Growth Factor beta; 0/Tumor Necrosis Factor-alpha; EC 2.7.11.1/Protein-Serine-Threonine Kinases; EC 2.7.11.30/transforming growth factor-beta type II receptor |
| Comments/Corrections | |
Comment In:
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Heart Rhythm. 2009 Dec;6(12):1751-3
[PMID:
19959124
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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