| Association of TCF7L2 SNPs with Age of Onset of Type 2 Diabetes and Proinsulin/Insulin Ratio but not with Glucagon Like Peptide 1. | |
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MedLine Citation:
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PMID: 21384500 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: Variants in TCF7L2 have been associated with the age of onset of type 2 diabetes in Mexican Americans. However, there is a lack of data on this relationship in Caucasians. Furthermore, risk alleles in TCF7L2 have been suggested to account for decreased conversion of proinsulin to insulin and decreased expression of glucagon like peptide 1. We investigated the impact of the allelic variants rs1225537 and rs7903146 in TCF7L2 on the age of onset of type 2 diabetes, the plasma concentrations of proinsulin and glucagon like peptide 1, and the ratio of proinsulin to insulin in a German cohort. METHODS: We studied 3185 participants of the LUdwigshafen RIsk and Cardiovascular health study. Among these 1021 subjects had type 2 diabetes. Data on age of onset of diabetes were available in 925 subjects. Oral glucose tolerance tests were performed in a subgroup not previously known to have diabetes. RESULTS: Carriers of the risk alleles in rs1225537 and rs7901346 had increased risk of type 2 diabetes and elevated HbA1c (all p < 0.001). The risk alleles were also associated with early onset of type 2 diabetes, decreased insulin secretion and markedly increased proinsulin and proinsulin to insulin ratio (all p < 0.03). Glucagon like peptide 1 was not significantly related to the TCF7L2 genotype. CONCLUSIONS: Our data demonstrate that TCF7L2 determines the age onset of type 2 diabetes in Caucasians and affects the conversion of proinsulin to insulin. However, TCF7L2 is not consistently associated with fasting glucagon like peptide 1. Copyright © 2011 John Wiley & Sons, Ltd. |
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Authors:
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Guenther Silbernagel; Wilfried Renner; Tanja B Grammer; Sigrun R Hügl; Julia Bertram; Marcus E Kleber; Michael M Hoffmann; Bernhard R Winkelmann; Winfried März; Bernhard O Boehm |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-3-8 |
Journal Detail:
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Title: Diabetes/metabolism research and reviews Volume: - ISSN: 1520-7560 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-3-8 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100883450 Medline TA: Diabetes Metab Res Rev Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 John Wiley & Sons, Ltd. |
Affiliation:
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Division of Endocrinology, Diabetology, Nephrology, Vascular Disease, and Clinical Chemistry, Department of Internal Medicine, Eberhard-Karls-University Tübingen, Tübingen, Germany. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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