| Association study of vascular endothelial growth factor and polymorphisms of its gene with ectopic pregnancy. | |
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MedLine Citation:
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PMID: 20015329 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PROBLEM: In ectopic pregnancy, increased levels of vascular endothelial growth factor are present. The aims of this study were to determine the association between -634C/G, -460T/C, and +936C/T vascular endothelial growth factor (VEGF) polymorphisms and ectopic pregnancy, and to determine whether serum levels of VEGF were affected by genetic factors. METHOD: of study This is a case-control study wherein 74 women with a history of ectopic pregnancy in a tertiary care center were compared to 134 post-menopausal controls with two pregnancies and no ectopic pregnancy for the genotyping of VEGF polymorphisms. For 35 patients with the diagnosis of ectopic pregnancy, serum concentrations of VEGF were obtained before the treatment. Genotyping of VEGF (-634C/G, -460T/C, and +936C/T) polymorphisms was performed by PCR, followed by endonuclease digestion. ELISA was performed to evaluate the VEGF serum levels. RESULTS: The -634C/G, -460T/C, and +936C/T VEGF polymorphisms were not associated with ectopic pregnancy (P = 0.170, P = 0.285, and P = 0.700, respectively). The serum levels of VEGF were not associated with the genotype of -634C/G, -460T/C, and +936C/T VEGF polymorphisms (P = 0.702; P = 0.347, and P = 0.256, respectively). CONCLUSION: There was no association between ectopic pregnancy and -634C/G, -460T/C, and +936C/T VEGF polymorphisms. There was no correlation between VEGF genotype and the expression of VEGF in blood samples. |
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Authors:
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Julio Elito; Silvia Daher; Marcelo Oct?vio Fernandes da Silva; Natali Maiumi Higashi Marconi; Karen Priscilla Tezotto Pendeloski; Antonio Fernandes Moron; Luiz Camano |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-12-15 |
Journal Detail:
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Title: American journal of reproductive immunology (New York, N.Y. : 1989) Volume: 63 ISSN: 1600-0897 ISO Abbreviation: Am. J. Reprod. Immunol. Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-01-12 Completed Date: 2010-03-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8912860 Medline TA: Am J Reprod Immunol Country: Denmark |
Other Details:
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Languages: eng Pagination: 120-5 Citation Subset: IM |
Affiliation:
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Department of Obstetrics of the Federal University of S?o Paulo, S?o Paulo, SP, Brazil. elitojjr@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Alleles Base Sequence Brazil Case-Control Studies DNA Primers / genetics Female Gene Frequency Genotype Haplotypes Humans Middle Aged Polymerase Chain Reaction Polymorphism, Single Nucleotide* Pregnancy Pregnancy, Ectopic / blood, genetics* Vascular Endothelial Growth Factor A / blood, genetics* |
| Chemical | |
Reg. No./Substance:
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0/DNA Primers; 0/VEGFA protein, human; 0/Vascular Endothelial Growth Factor A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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