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Association Study of Interferon Gamma (IFN-γ) +874T/A Gene Polymorphism in Patients with Paranoid Schizophrenia.
MedLine Citation:
PMID:  20821074     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Schizophrenia is a multifactorial disease with changes affecting the immune system. Dysregulation of the cytokine network in schizophrenia has been well documented. Such changes may occur due to disturbances in cytokine levels that are linked to polymorphisms of cytokine genes. However, research in the role of cytokine gene polymorphisms in schizophrenia has been surprisingly scanty. The aim of this study was to identify, in a case control study, whether polymorphism of IFN-γ gene is a risk factor for the development of paranoid schizophrenia. To the best of our knowledge, this is the first study that examines the association between the IFN-γ gene polymorphism and psychopathological symptoms in patients with paranoid schizophrenia. Polymorphism of IFN-γ (+874T/A, rs 62559044) in schizophrenic patients (n = 179), as well as healthy individuals (n = 196), both Polish residents, was genotyped using AS-PCR method. Of note, when analyzing the results, we took into consideration the gender of studied individuals. Surprisingly, a single-nucleotide polymorphism in the first intron of the IFN-γ gene was found to be associated with paranoid schizophrenia in males, but not in females. The presence of allele A at position +874 in the IFN-γ gene correlates with 1.66-fold higher risk of paranoid schizophrenia development in males. Differences in the genotypes may have an important role in determining the level of I gene transcription. Because other polymorphisms have been demonstrated to influence IFN-γ transcription, further analysis is necessary to clarify the role of this gene in the pathogenesis of paranoid schizophrenia.
Authors:
Monika Paul-Samojedny; Aleksander Owczarek; Renata Suchanek; Malgorzata Kowalczyk; Anna Fila-Danilow; Paulina Borkowska; Krzysztof Kucia; Jan Kowalski
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Publication Detail:
Type:  Journal Article     Date:  2010-09-04
Journal Detail:
Title:  Journal of molecular neuroscience : MN     Volume:  43     ISSN:  1559-1166     ISO Abbreviation:  J. Mol. Neurosci.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-02-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9002991     Medline TA:  J Mol Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  309-15     Citation Subset:  IM    
Affiliation:
Department of Medical Genetics, Medical University of Silesia, 30, Ostrogorska Street, 41-200, Sosnowiec, Poland, mpaul@sum.edu.pl.
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