| Association of Serum and Crevicular Visfatin Levels in Periodontal Health and Disease With Type 2 Diabetes Mellitus. | |
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MedLine Citation:
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PMID: 21966944 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Summary: Levels of Visfatin in serum and GCF were explored in periodontal health and disease with type 2 Diabetes Mellitus, and were found to be elevated with periodontal disease; they also correlated positively with periodontal clinical parameters. Objective: Diabetes Mellitus and chronic periodontitis (CP) are associated with each other. Adipokines, specifically Visfatin, are secreted from adipocytes and are thought to cause insulin resistance. The purpose of this study is to determine the presence of Visfatin in serum and gingival crevicular fluid (GCF) in type 2 Diabetes Mellitus (t2 DM) among CP subjects and to find an association, if any. Material and Methods: 30 subjects (15 males and 15 females) were selected based on their clinical parameters into three groups: Group 1 (10 healthy), Group 2 [10 well controlled t2 DM among CP subjects and Group 3 (10 non-diabetic CP subjects). Serum and GCF samples were collected to estimate the levels of Visfatin using Enzyme Linked Immunosorbent Assay. Results: The mean Visfatin concentration increased both in serum and GCF in subjects with t2 DM with CP. Also, it was observed that visfatin both in serum and GCF correlated positively with all the periodontal parameters. Conclusions: All the samples in each group tested positive for Visfatin assay. Serum and GCF visfatin concentration both in t2 DM with CP and non diabetic CP subjects correlated positively with all the clinical parameters. Further large scale longitudinal studies should be carried out to confirm positive correlations. |
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Authors:
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Ar Pradeep; Nm Raghavendra; Rahul Kathariya; Swati Pradeep Patel; P Arjun Raju; Anuj Sharma |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-10-3 |
Journal Detail:
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Title: Journal of periodontology Volume: - ISSN: 1943-3670 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-4 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8000345 Medline TA: J Periodontol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Periodontics, Government Dental College and Research Institute, Bangalore, India. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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