Document Detail

Association of self-reported physical activity with laboratory markers of nutrition and inflammation: the Comprehensive Dialysis Study.
MedLine Citation:
PMID:  21239185     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Patients on dialysis maintain extremely low levels of physical activity. Prior studies have demonstrated a direct correlation between nutrition and physical activity but provide conflicting data on the link between inflammation and physical activity. Using a cohort of patients new to dialysis from the Comprehensive Dialysis Study (CDS), we examined associations of self-reported physical activity with laboratory markers of nutrition and inflammation.
DESIGN, SETTING, AND PATIENTS: Between June 2005 and June 2007, CDS collected data on self-reported physical activity, nutrition, and health-related quality of life from patients starting dialysis in 296 facilities located throughout the United States. Baseline serum samples were collected from participants in a nutrition sub-study of CDS.
MEASURES: Serum albumin and prealbumin were measured as markers of nutrition, and C-reactive protein (CRP) and α-1-acid glycoprotein as markers of inflammation. Self-reported physical activity was characterized by the maximum activity score (MAS) and adjusted activity score (AAS) of the Human Activity Profile.
RESULTS: The mean age of participants in the analytic cohort (n = 201) was 61 years. The MAS and AAS were below the 10th and first percentile, respectively, in comparison with healthy 60 year-old norms. Both activity scores were directly correlated with albumin (r(2) = 0.3, P < .0001) and prealbumin (r(2) = 0.3, P < .0001), and inversely correlated with CRP (AAS: r(2) = -0.2, P = .01; MAS: r(2) = -0.1, P = .08). In multivariate analyses adjusting for age, gender, race/ethnicity, diabetes status, and center, both activity scores were directly correlated with prealbumin and inversely correlated with CRP.
CONCLUSIONS: Patients new to dialysis with laboratory-based evidence of malnutrition and/or inflammation are likely to report lower levels of physical activity.
Shuchi Anand; Glenn M Chertow; Kirsten L Johansen; Barbara Grimes; Manjula Kurella Tamura; Lorien S Dalrymple; George A Kaysen
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-01-15
Journal Detail:
Title:  Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation     Volume:  21     ISSN:  1532-8503     ISO Abbreviation:  J Ren Nutr     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-10-24     Completed Date:  2012-02-16     Revised Date:  2013-07-02    
Medline Journal Info:
Nlm Unique ID:  9112938     Medline TA:  J Ren Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  429-37     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 National Kidney Foundation, Inc. All rights reserved.
Division of Nephrology, Department of Medicine, Stanford University School of Medicine, Palo Alto, California, USA.
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MeSH Terms
Biological Markers / analysis*
C-Reactive Protein / analysis
Cohort Studies
Cross-Sectional Studies
Inflammation / pathology*
Kidney Failure, Chronic / therapy
Middle Aged
Motor Activity*
Multivariate Analysis
Nutritional Status*
Orosomucoid / analysis
Prealbumin / analysis
Quality of Life
Renal Dialysis*
Self Report
Serum Albumin / analysis
United States
Grant Support
F32 DK 084697/DK/NIDDK NIH HHS; F32 DK084697-01/DK/NIDDK NIH HHS; K24 DK 080645/DK/NIDDK NIH HHS; K24 DK085446/DK/NIDDK NIH HHS; K24 DK085446-02/DK/NIDDK NIH HHS; N01 DK012450/DK/NIDDK NIH HHS; N01-DK-7-0005/DK/NIDDK NIH HHS
Reg. No./Substance:
0/Biological Markers; 0/Orosomucoid; 0/Prealbumin; 0/Serum Albumin; 9007-41-4/C-Reactive Protein

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