| Association of self-reported physical activity with laboratory markers of nutrition and inflammation: the Comprehensive Dialysis Study. | |
| | |
MedLine Citation:
|
PMID: 21239185 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: Patients on dialysis maintain extremely low levels of physical activity. Prior studies have demonstrated a direct correlation between nutrition and physical activity but provide conflicting data on the link between inflammation and physical activity. Using a cohort of patients new to dialysis from the Comprehensive Dialysis Study (CDS), we examined associations of self-reported physical activity with laboratory markers of nutrition and inflammation. DESIGN, SETTING, AND PATIENTS: Between June 2005 and June 2007, CDS collected data on self-reported physical activity, nutrition, and health-related quality of life from patients starting dialysis in 296 facilities located throughout the United States. Baseline serum samples were collected from participants in a nutrition sub-study of CDS. MEASURES: Serum albumin and prealbumin were measured as markers of nutrition, and C-reactive protein (CRP) and α-1-acid glycoprotein as markers of inflammation. Self-reported physical activity was characterized by the maximum activity score (MAS) and adjusted activity score (AAS) of the Human Activity Profile. RESULTS: The mean age of participants in the analytic cohort (n = 201) was 61 years. The MAS and AAS were below the 10th and first percentile, respectively, in comparison with healthy 60 year-old norms. Both activity scores were directly correlated with albumin (r(2) = 0.3, P < .0001) and prealbumin (r(2) = 0.3, P < .0001), and inversely correlated with CRP (AAS: r(2) = -0.2, P = .01; MAS: r(2) = -0.1, P = .08). In multivariate analyses adjusting for age, gender, race/ethnicity, diabetes status, and center, both activity scores were directly correlated with prealbumin and inversely correlated with CRP. CONCLUSIONS: Patients new to dialysis with laboratory-based evidence of malnutrition and/or inflammation are likely to report lower levels of physical activity. |
| | |
Authors:
|
Shuchi Anand; Glenn M Chertow; Kirsten L Johansen; Barbara Grimes; Manjula Kurella Tamura; Lorien S Dalrymple; George A Kaysen |
Related Documents
:
|
8200895 - Skeletal-extraskeletal angiomatosis. a clinicopathological study of fourteen patients a... 16370155 - The effects of lanthanum carbonate and calcium carbonate on bone abnormalities in patie... 9609175 - The linear intravertebral vacuum: a sign of benign vertebral collapse. 7655175 - Bone loss in patients with inflammatory bowel disease: a prospective study. 8651965 - N-[4-hydroxyphenyl] retinamide in rheumatoid arthritis: a pilot study. 11588315 - Role of conventional angiography in evaluation of patients with carotid artery stenosis... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural Date: 2011-01-15 |
Journal Detail:
|
Title: Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation Volume: 21 ISSN: 1532-8503 ISO Abbreviation: J Ren Nutr Publication Date: 2011 Nov |
Date Detail:
|
Created Date: 2011-10-24 Completed Date: 2012-02-16 Revised Date: 2013-02-19 |
Medline Journal Info:
|
Nlm Unique ID: 9112938 Medline TA: J Ren Nutr Country: United States |
Other Details:
|
Languages: eng Pagination: 429-37 Citation Subset: IM |
Copyright Information:
|
Copyright © 2011 National Kidney Foundation, Inc. All rights reserved. |
Affiliation:
|
Division of Nephrology, Department of Medicine, Stanford University School of Medicine, Palo Alto, California, USA. sanand2@stanford.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Biological Markers / analysis* C-Reactive Protein / analysis Cohort Studies Cross-Sectional Studies Female Humans Inflammation / pathology* Kidney Failure, Chronic / therapy Male Malnutrition Middle Aged Motor Activity* Multivariate Analysis Nutritional Status* Orosomucoid / analysis Prealbumin / analysis Quality of Life Renal Dialysis* Self Report Serum Albumin / analysis United States |
| Grant Support | |
ID/Acronym/Agency:
|
F32 DK 084697/DK/NIDDK NIH HHS; F32 DK084697-01/DK/NIDDK NIH HHS; K24 DK 080645/DK/NIDDK NIH HHS; K24 DK085446/DK/NIDDK NIH HHS; K24 DK085446-02/DK/NIDDK NIH HHS; N01 DK012450/DK/NIDDK NIH HHS; N01-DK-7-0005/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Biological Markers; 0/Orosomucoid; 0/Prealbumin; 0/Serum Albumin; 9007-41-4/C-Reactive Protein |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Vitamin D: The Iceberg Nutrient.
Next Document: Appetite and Gastrointestinal Symptoms in Chronic Hemodialysis Patients.