| Association of selenium status and blood glutathione concentrations in blacks and whites. | |
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MedLine Citation:
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PMID: 21462082 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Selenium deficiency has been linked with increased cancer risk and, in some studies, selenium supplementation was protective against certain cancers. Previous studies have suggested that selenium chemoprevention may involve reduced oxidative stress through enhanced glutathione (GSH). Our objectives were to examine the relationships between selenium and GSH in the blood and the modifying effects of race and sex in free-living adults and individuals supplemented with selenium. Plasma selenium concentrations and free and bound GSH concentrations and γ-glutamyl cysteine ligase (GCL) activity in the blood were measured in 336 healthy adults (161 Blacks, 175 Whites). Plasma selenium and blood GSH were also measured in 36 healthy men from our previously conducted placebo-controlled trial of selenium-enriched yeast (247 μg/day for 9 mo). In free-living adults, selenium concentrations were associated with increased blood GSH concentration and GCL activity (P < 0.05). Further, selenium was significantly higher in Whites than in Blacks (P < 0.01). After 9 mo of supplementation, plasma selenium increased 114% in Whites and 50% in Blacks (P < 0.05), and blood GSH increased 35% in Whites (P < 0.05) but was unchanged in Blacks. These results indicate a direct association between selenium and GSH in the blood of both free-living and selenium-supplemented individuals, with race being an important modifying factor. |
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Authors:
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John P Richie; Joshua E Muscat; Irina Ellison; Ana Calcagnotto; Wayne Kleinman; Karam El-Bayoumy |
Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Nutrition and cancer Volume: 63 ISSN: 1532-7914 ISO Abbreviation: Nutr Cancer Publication Date: 2011 |
Date Detail:
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Created Date: 2011-04-14 Completed Date: 2011-08-15 Revised Date: 2012-04-04 |
Medline Journal Info:
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Nlm Unique ID: 7905040 Medline TA: Nutr Cancer Country: England |
Other Details:
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Languages: eng Pagination: 367-75 Citation Subset: IM |
Affiliation:
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Department of Public Health Sciences, Penn State Hershey Cancer Institute, Penn State University College of Medicine, Hershey, Pennsylvania 17033, USA. jrichie@psu.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult African Continental Ancestry Group* Analysis of Variance Antioxidants / administration & dosage Biological Availability Biological Markers Dietary Supplements Double-Blind Method European Continental Ancestry Group* Female Glutathione / blood*, drug effects Humans Intervention Studies Male Middle Aged New York Oxidative Stress Selenium / administration & dosage*, blood* Smoking Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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K07 CA104231-05/CA/NCI NIH HHS; K07-CA104231/CA/NCI NIH HHS; P01 CA068384-08/CA/NCI NIH HHS; P01 CA070972-09/CA/NCI NIH HHS; P01 CA68384/CA/NCI NIH HHS; P01 CA70972/CA/NCI NIH HHS; R01 CA127729/CA/NCI NIH HHS; R01 CA127729-04/CA/NCI NIH HHS; R01 CA127729-05/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Biological Markers; 70-18-8/Glutathione; 7782-49-2/Selenium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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