Document Detail

Association of ST2 levels with cardiac structure and function and mortality in outpatients.
MedLine Citation:
PMID:  20934567     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: ST2, an interleukin-1 receptor family member up-regulated in the setting of cardiomyocyte strain, has prognostic value in patients with acute myocardial infarction, chronic severe heart failure, and acute heart failure. The predictive value of ST2 levels in outpatients is unknown. We studied the clinical and echocardiographic correlates of ST2 levels and evaluated their prognostic use in outpatients referred for echocardiograms. METHODS: ST2 levels were measured in 588 outpatients referred for echocardiogram. Subjects were analyzed by quartile as well as by optimal ST2 cut-point (28.25 ng/mL) derived from receiver operating characteristic curve analysis. All-cause death at 1 year was the primary outcome. RESULTS: In this cohort with mean age of 68 ± 12 years and median ST2 level of 19.8 ng/mL (interquartile range 15.8-23.7), 25 deaths occurred. Heart rate, creatinine clearance, use of diuretics, and the presence of right ventricular hypokinesis were independently associated with ST2 levels. At 6 months, no patients with ST2 below the median had died. Patients with high ST2 levels had an increased risk of death (adjusted hazard ratio [HR] 2.5, P = .02); those with elevated levels of both ST2 and B-type natriuretic peptide were at even higher risk (adjusted HR 4.3, P = .01 vs none elevated). CONCLUSIONS: ST2 levels reflect right-side heart size and function and are independent predictors of 1-year mortality in outpatients referred for echocardiograms. The optimal cut-point derived in this cohort is comparable with the previously identified prognostic cut-point for sicker patients. ST2 may be an especially strong prognostic marker for short-term mortality risk.
Lori B Daniels; Paul Clopton; Navaid Iqbal; Kimberly Tran; Alan S Maisel
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  American heart journal     Volume:  160     ISSN:  1097-6744     ISO Abbreviation:  Am. Heart J.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-11     Completed Date:  2010-10-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  721-8     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2010 Mosby, Inc. All rights reserved.
Division of Cardiology, Department of Medicine, University of California at San Diego, San Diego, CA, USA.
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MeSH Terms
California / epidemiology
Cause of Death / trends
Echocardiography, Doppler, Color / methods*
Enzyme-Linked Immunosorbent Assay
Follow-Up Studies
Heart Atria / physiopathology,  ultrasonography*
Heart Diseases / blood*,  mortality,  ultrasonography
Heart Ventricles / physiopathology,  ultrasonography*
Middle Aged
Myocardial Contraction / physiology*
Myocardium / metabolism
Receptors, Cell Surface / metabolism*
Receptors, Interleukin-1
Retrospective Studies
Survival Rate / trends
Reg. No./Substance:
0/IL1RL1 protein, human; 0/Receptors, Cell Surface; 0/Receptors, Interleukin-1

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