Document Detail


Association of single-nucleotide polymorphisms from 17 candidate genes with baseline symptom-limited exercise test duration and decrease in duration over 20 years: the Coronary Artery Risk Development in Young Adults (CARDIA) fitness study.
MedLine Citation:
PMID:  20952631     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: It is not known whether the genes involved with endurance performance during young adulthood are also involved with changes in performance. We examined the associations of gene variants with symptom-limited exercise test duration at baseline and decrease in duration over 20 years.
METHODS AND RESULTS: A total of 3783 (1835 black, 1948 white) and 2335 (1035 black, 1300 white) participants from the Coronary Artery Risk Development in Young Adults study were included in the baseline and 20-year models, respectively. Two hundred seventeen single-nucleotide polymorphisms (SNPs) in black participants and 171 in white participants from 17 genes were genotyped. In blacks, 5 SNPs in the ATP1A2, HIF1A, NOS3, and PPARGC1A loci tended to be associated (P<0.05) with baseline duration in a multivariate regression model. Blacks (n=99) with at least 4 of the most-favorable genotypes at these loci had an ≈2-minute longer baseline duration than those with only 2 such genotypes (P<0.0001). In whites, the HIF1A rs1957757 and PPARGC1A rs3774909 markers tended to be associated with baseline duration, but the association of a multimarker construct of the most-favorable genotypes at both SNPs with baseline duration was not statistically significant. In whites, 4 SNPs in the AGT, AMPD1, ANG, and PPARGC1A loci tended to be associated with decrease in exercise duration over 20 years, and those with all 4 favorable genotypes (n=40) had a 0.8-minute less decline in duration compared with those with none or 1 (n=232) (P<0.0001).
CONCLUSIONS: In multimarker constructs, alleles at genes related to skeletal muscle Na(+)/K(+) transport, hypoxia, and mitochondrial metabolism are associated with symptom-limited exercise test duration over time in adults.
Authors:
Mark A Sarzynski; Tuomo Rankinen; Barbara Sternfeld; Megan L Grove; Myriam Fornage; David R Jacobs; Stephen Sidney; Claude Bouchard
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2010-10-15
Journal Detail:
Title:  Circulation. Cardiovascular genetics     Volume:  3     ISSN:  1942-3268     ISO Abbreviation:  Circ Cardiovasc Genet     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-15     Completed Date:  2011-05-10     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  101489144     Medline TA:  Circ Cardiovasc Genet     Country:  United States    
Other Details:
Languages:  eng     Pagination:  531-8     Citation Subset:  IM    
Affiliation:
Human Genomics Laboratory, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Age Factors
Anoxia / genetics
Exercise Test*
Exercise Tolerance / genetics*
Female
Genotype
Humans
Longitudinal Studies
Male
Mitochondria / metabolism
Muscle, Skeletal / enzymology
Physical Fitness
Polymorphism, Single Nucleotide / physiology*
Sodium-Potassium-Exchanging ATPase / genetics
Time Factors
Young Adult
Grant Support
ID/Acronym/Agency:
HL45670/HL/NHLBI NIH HHS; N01 HC048050/HC/NHLBI NIH HHS; N01-HC-48047/HC/NHLBI NIH HHS; N01-HC-48048/HC/NHLBI NIH HHS; N01-HC-48049/HC/NHLBI NIH HHS; N01-HC-48050/HC/NHLBI NIH HHS; N01-HC-95095/HC/NHLBI NIH HHS; R01 HL 078972/HL/NHLBI NIH HHS; R01 HL078972-04/HL/NHLBI NIH HHS; R01 NS 070914/NS/NINDS NIH HHS; RC2 HL 101666/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
EC 3.6.3.9/Sodium-Potassium-Exchanging ATPase
Comments/Corrections

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