Document Detail

Association of reduced zinc status with angiographically severe coronary atherosclerosis: a pilot study.
MedLine Citation:
PMID:  20529979     Owner:  NLM     Status:  MEDLINE    
In vitro studies attribute antiatherogenic and insulin-like properties to zinc (Zn). However, only a few conflicting clinical data exist concerning the relationship between Zn and coronary artery disease (CAD) as well as glycemic indices. We studied 72 patients without prior history of myocardial infarction or revascularization procedures, who underwent coronary angiography for evaluation of chest pain. Coronary artery disease severity was estimated using 3 angiographic scores. Zn in serum and 24-hour urine, as well as serum Zn/24-hour urine Zn ratio were determined. Serum Zn was not associated with CAD prevalence and severity. However, urinary Zn loss was significantly higher among patients with CAD and showed a positive association with CAD severity. Serum Zn/24-hour urine Zn ratio was inversely associated with CAD, as well as with diabetes mellitus prevalence, fasting glucose, and glycated hemoglobin levels. Low serum Zn/24-hour urine Zn ratio is associated with angiographically severe atherosclerosis and impaired glucose homeostasis.
George D Giannoglou; Dimitris M Konstantinou; Leda Kovatsi; Yiannis S Chatzizisis; Dimitri P Mikhailidis
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Publication Detail:
Type:  Journal Article     Date:  2010-06-07
Journal Detail:
Title:  Angiology     Volume:  61     ISSN:  1940-1574     ISO Abbreviation:  Angiology     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-28     Completed Date:  2010-07-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0203706     Medline TA:  Angiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  449-55     Citation Subset:  IM    
1st Cardiology Department, AHEPA University Hospital, Aristotle University Medical School, Thessaloniki, Greece.
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MeSH Terms
Angina Pectoris / metabolism,  radiography
Blood Glucose / metabolism
Coronary Angiography*
Coronary Artery Disease / metabolism*,  radiography*
Coronary Stenosis / metabolism,  radiography
Diabetes Mellitus, Type 2 / metabolism,  radiography
Hemoglobin A, Glycosylated / metabolism*
Middle Aged
Pilot Projects
Risk Factors
Statistics as Topic
Zinc / deficiency*,  metabolism*
Reg. No./Substance:
0/Blood Glucose; 0/Hemoglobin A, Glycosylated; 0/hemoglobin A1c protein, human; 7440-66-6/Zinc

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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