| Association of RS2200733 but not RS10033464 on 4q25 with atrial fibrillation based on the recessive model in a taiwanese population. | |
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MedLine Citation:
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PMID: 20606429 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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OBJECTIVES: To determine the association between genetic variants on chromosome 4q25 and atrial fibrillation (AF) in a Taiwanese population. METHODS: We enrolled 200 patients with AF (mean age: 67 +/- 13 years) and 158 controls (mean age: 63 +/- 10 years). The genotypes of five SNPs, RS2634073, RS2200733, RS13143308, RS2220427 and RS10033464, were determined using multiplex single base extension methods. RESULTS: The distribution of the RS2200733 and RS10033464 genotypes did not significantly deviate from the Hardy-Weinberg equilibrium in the control group. The distribution of the RS2200733 genotypes differed significantly between the AF group and the controls (p = 0.03), whereas the distribution of the RS10033464 genotypes did not (p = 0.49). At RS2200733, patients with the CC genotype exhibited a 0.45 times higher risk of developing AF than those with the TT genotype (p = 0.02) and a recessive model was suggested (p = 0.01). After adjusting for various covariates, patients with the CC genotype remained recessively associated with a lower risk of developing AF than those with the TT genotype (odds ratio: 0.27, 95% confidence interval: 0.11-0.65; p < 0.01). CONCLUSIONS: In the Taiwanese, there is an association between SNP RS2200733 - but not RS10033464 - and the development of AF. Based on a recessive model of inheritance, individuals with SNP RS2200733 genotype CC are at a lesser risk of developing AF. |
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Authors:
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Kun-Tai Lee; Hi-Yin Yeh; Chung-Po Tung; Chih-Sheng Chu; Kai-Hung Cheng; Wei-Chung Tsai; Ye-Hsu Lu; Jan-Gowth Chang; Sheng-Hsiung Sheu; Wen-Ter Lai |
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Publication Detail:
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Type: Journal Article Date: 2010-07-07 |
Journal Detail:
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Title: Cardiology Volume: 116 ISSN: 1421-9751 ISO Abbreviation: Cardiology Publication Date: 2010 |
Date Detail:
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Created Date: 2010-08-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 1266406 Medline TA: Cardiology Country: Switzerland |
Other Details:
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Languages: eng Pagination: 151-6 Citation Subset: IM |
Copyright Information:
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Copyright 2010 S. Karger AG, Basel. |
Affiliation:
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Department of Internal Medicine, College of Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, ROC. kuntai.lee@msa.hinet.net |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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