| Association of the Pro12Ala and C1431T Variants of PPAR{gamma} and Their Haplotypes with Susceptibility to Gestational Diabetes. | |
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MedLine Citation:
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PMID: 21795447 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background: The protective role of the Ala allele in the Pro12Ala polymorphism of PPARγ on type 2 diabetes has been well established but not confirmed in the context of pregnancy, for gestational diabetes, a known predictor of later type 2 diabetes onset. Another PPARγ polymorphism, the C1431T, is in strong linkage disequilibrium with Pro12Ala and has been shown to be associated with body weight, but its association with diabetes is controversial. Research Design and Methods: In 1708 women of the EDEN mother-child cohort, the PPARγ Pro12Ala and C1431T polymorphisms were genotyped and analyzed in association with maternal prepregnancy body mass index, obesity before pregnancy, and gestational diabetes, separately and also combined in haplotypes. Results: The prevalence of obesity was significantly higher in mothers with the Ala/Ala genotype compared with carriers of the Pro allele (35 vs. 9%, P < 0.0001), but there was no cases of gestational diabetes in Ala/Ala mothers. Mothers homozygous for the T allele of C1431T were also more obese (24 vs. 9%, P = 0.035), and three times more had gestational diabetes (18 vs. 6%, P = 0.044). Frequencies of haplotypes for these two single-nucleotide polymorphisms differed significantly in mothers with and without gestational diabetes; in comparison with the Pro-C haplotype, the Pro-T haplotype conferred the highest risk [odds ratio (95% CI) = 1.89 (1.05-3.40)], and the Ala-C the lowest risk [odds ratio (95% CI) = 0.12 (0.52-1.70)]. Conclusions: These results from a haplotype analysis, show for the first time that genetic variations in the PPARγ gene could play a role in the susceptibility to develop gestational diabetes. |
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Authors:
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Barbara Heude; Veronique Pelloux; Anne Forhan; Jean-François Bedel; Jean-Marc Lacorte; Karine Clément; Marie-Aline Charles; |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-7-27 |
Journal Detail:
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Title: The Journal of clinical endocrinology and metabolism Volume: - ISSN: 1945-7197 ISO Abbreviation: - Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-7-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Institut National de la Santé et de la Recherche Médicale (INSERM) (B.H., A.F., M.-A.C.), Centre de recherche en Epidémiologie et Santé des Populations Centre for Research in Epidemiology and Population Health, UMRS1018 Team 10, Lifelong Epidemiology of Diabetes, Obesity, and Chronic Kidney Disease, and Université Paris-Sud (B.H., A.F., M.-A.C.), Unité Mixte de Recherche en Santé (UMRS) 1018, F-94807 Villejuif, France; INSERM (V.P., J.-F.B., K.C.), U872, Team 7, Nutriomique, and University Pierre et Marie Curie-Paris 6 (V.P., J.-M.L., K.C.), Cordelier Research Center, UMRS 872, F-75006 Paris, France; and Assistance Publique/Hôpitaux de Paris (AP/HP) (V.P., J.-F.B., K.C.), Pitié Salpêtrière Hospital, Nutrition and Endocrinology Department, Research Center for Human Nutrition (CRNH, Ile de France), and Département de Biochimie Endocrinienne et Oncologique (J.-M.L.), Unité Fonctionnelle de Nutrigenetique, Hôpital Pitié-Salpêtrière, AP-HP, F-75013 Paris, France. |
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