| Association of a Polymorphism of BTN2A1 With Hypertension in Japanese Individuals. | |
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MedLine Citation:
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PMID: 21525964 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BackgroundWe previously showed that the C→T polymorphism (rs6929846) in butyrophilin, subfamily 2, member A1 gene (BTN2A1) was associated with myocardial infarction in Japanese individuals. Given that hypertension is a major risk factor for myocardial infarction, the association of rs6929846 of BTN2A1 with myocardial infarction might be attributable, at least in part, to its effect on susceptibility to hypertension. We have thus examined the relation of rs6929846 of BTN2A1 to hypertension in Japanese individuals.MethodsA total of 8,567 Japanese individuals from two independent subject panels were examined: Subject panels A and B comprised 2,317 hypertensive individuals and 1,933 controls, and 2,911 hypertensive individuals and 1,406 controls, respectively. The genotype of rs6929846 was determined by a method that combines the PCR and sequence-specific oligonucleotide probes with suspension array technology.ResultsMultivariable logistic regression analysis with adjustment for covariates revealed that rs6929846 of BTN2A1 was significantly associated with hypertension in subject panel A (P = 2.6 × 10(-6); odds ratio, 1.69) and in subject panel B (P = 0.0284; odds ratio, 1.24), with the T allele representing a risk factor for hypertension. The rs6929846 was associated with systolic blood pressure (BP) in subject panels A (P = 0.0063) and B (P = 0.0115) and with diastolic BP in subject panel B (P = 0.0323), with the T allele being related to high BP.ConclusionsBTN2A1 may be a susceptibility gene for hypertension in Japanese individuals. Determination of genotype for this polymorphism may prove informative for assessment of the genetic risk for hypertension.American Journal of Hypertension (2011). doi:10.1038/ajh.2011.74. |
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Authors:
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Hideki Horibe; Kimihiko Kato; Mitsutoshi Oguri; Tetsuro Yoshida; Tetsuo Fujimaki; Toshiki Kawamiya; Kiyoshi Yokoi; Sachiro Watanabe; Kei Satoh; Yukitoshi Aoyagi; Masashi Tanaka; Hiroto Yoshida; Shoji Shinkai; Yoshinori Nozawa; Toyoaki Murohara; Yoshiji Yamada |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-4-28 |
Journal Detail:
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Title: American journal of hypertension Volume: - ISSN: 1879-1905 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-4-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8803676 Medline TA: Am J Hypertens Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Cardiovascular Medicine, Gifu Prefectural Tajimi Hospital, Tajimi, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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