| The association of patent foramen ovale morphology and stroke size in patients with paradoxical embolism. | |
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MedLine Citation:
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PMID: 20858864 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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BACKGROUND: Patent foramen ovale (PFO) has been implicated in the pathogenesis of cryptogenic stroke through paradoxical embolization to the cerebral circulation. This study evaluated the relationship between the morphological and functional size of the PFO by echocardiography compared with cerebral infarct volume identified on MRI. METHODS AND RESULTS: Patients who were referred to interventional cardiology with the diagnosis of cryptogenic stroke were included and had either a transesophageal echocardiogram or an intracardiac echo and a brain MRI at the time of stroke. Transesophageal echocardiogram or intracardiac echo was used to obtain PFO measurements. MRI of the brain with 3 sequences (T2, diffusion-weighted imaging, and fluid-attenuated inversion recovery) was used to diagnose acute stroke and measure the infarct volume. In the 72 patients studied, the median measured stroke volume was 4.3 cm(3) on diffusion-weighted imaging, 4.1 cm(3) on T2, and 3.5 cm(3) on fluid-attenuated inversion recovery. There was no significant correlation between the PFO height, length, septum secundum thickness, or echo bubble grade and the infarct volume measured from the 3 MRI sequences. There was a significant correlation between septal excursion distance and infarct volume (r=0.35; P=0.005), but the 12 patients with atrial septal aneurysm did not have the largest strokes. CONCLUSIONS: This analysis revealed that septal excursion distance correlates with stroke size by MRI. However, smaller PFO size without the presence of atrial septal aneurysm may still be associated with significant strokes. There was no significant association between PFO height, length by echo, or shunt grade by transcranial Doppler study and brain infarct volume. Therefore, PFO size or morphology should not be the only criteria to decide whether a PFO should be closed. |
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Authors:
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Andre Akhondi; Rubine Gevorgyan; Chi-Hong Tseng; Leo Slavin; Catherine Dao; David S Liebeskind; Jonathan M Tobis |
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Publication Detail:
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Type: Journal Article Date: 2010-09-21 |
Journal Detail:
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Title: Circulation. Cardiovascular interventions Volume: 3 ISSN: 1941-7632 ISO Abbreviation: Circ Cardiovasc Interv Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101499602 Medline TA: Circ Cardiovasc Interv Country: United States |
Other Details:
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Languages: eng Pagination: 506-10 Citation Subset: IM |
Affiliation:
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Department of Medicine, Cardiology Division, David Geffen School of Medicine at UCLA, Los Angeles, Calif., USA. aakhondi@ucla.edu |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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