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Association of PPP1R3B polymorphisms with blood lipid and CRP levels in Chinese population.
MedLine Citation:
PMID:  23343124     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: Genetic variants of PPP1R3B, a gene encoding a critical protein involved in hepatic glycogen metabolism were recently reported to be associated with plasma levels of lipids and C-reactive protein (CRP) among populations of mostly European descent. This study aimed to examine whether the PPP1R3B variants are associated with plasma levels of lipids and inflammation factors in Chinese Hans with different circulating profiles of these two phenotypes. METHOD: In this study, five SNPs of PPP1R3B gene were genotyped and their associations with plasma lipids and CRP were determined in 1,636 Chinese Hans. RESULTS: Three SNPs, namely rs2126259, rs9987289 and rs19334 were significantly associated with plasma levels of low-density lipoprotein cholesterol (LDL-C), and rs2126259 and rs9987289 were also significantly associated with total cholesterol. Moreover, the other two SNPs (rs189798 and rs330919) were significantly associated with plasma CRP level, but not with plasma lipid levels. CONCLUSION: PPP1R3B genetic polymorphisms may contribute to the variations of plasma lipid and CRP levels among Chinese Hans. THE SIGNIFICANCE OF THE STUDY: revealed that the genetic polymorphisms of PPP1R3B might influence the levels of circulating lipids and CRP levels among Chinese Hans. THIS STUDY ADDS: the associations of PPP1R3B gene polymorphism with cardiovascular disease risk factors in Chinese population.
Authors:
Yongxian Zhang; Wei Gan; Chuan Tian; Huaixing Li; Xu Lin; Yan Chen
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-24
Journal Detail:
Title:  Journal of diabetes     Volume:  -     ISSN:  1753-0407     ISO Abbreviation:  J Diabetes     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101504326     Medline TA:  J Diabetes     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2013 Ruijin Hospital, Shanghai Jiaotong University School of Medicine and Wiley Publishing Asia Pty Ltd.
Affiliation:
Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, China.
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