| Association of oncogenic and nononcogenic human papillomavirus with HIV incidence. | |
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MedLine Citation:
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PMID: 19779357 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Little is known about the interaction between human papillomavirus (HPV) and HIV. This study aimed to explore the association of oncogenic (high risk) and nononcogenic (low risk) HPV with HIV incidence. METHODS: We used 1683 urethral swabs collected at the last follow-up visit of a male circumcision trial conducted in Orange Farm (South Africa). Swabs analyses and HPV genotyping were performed by polymerase chain reaction. We estimated HIV adjusted incidence rate ratios (aIRRs) and 95% confidence intervals (CIs) using survival analysis. Background characteristics, male circumcision status, sexual behavior, HPV status, and other sexually transmitted infections were used as covariates. RESULTS: The prevalence of HR and LR HPV was 14.0% (95% CI: 12.4 to 15.7) and 17.3% (95% CI: 15.6 to 19.2), respectively. When controlling for HR-HPV status, LR-HPV status was not associated with HIV incidence (aIRR = 1.13, 95% CI: 0.40 to 3.16; P = 0.82). When controlling for all covariates, HIV incidence increased significantly with HR-HPV positivity (aIRR = 3.76, 95% CI: 1.83 to 7.73, P < 0.001) and with the number of HR-HPV genotypes (adjusted-P linear trend = 0.0074). CONCLUSIONS: Several explanations could account for our findings. One is that HR-HPV facilitates HIV acquisition. The association of HPV with HIV acquisition requires further investigations. |
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Authors:
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Bertran Auvert; Pascale Lissouba; Ewalde Cutler; Kevin Zarca; Adrian Puren; Dirk Taljaard |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of acquired immune deficiency syndromes (1999) Volume: 53 ISSN: 1944-7884 ISO Abbreviation: J. Acquir. Immune Defic. Syndr. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2009-12-29 Completed Date: 2010-01-19 Revised Date: 2011-10-31 |
Medline Journal Info:
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Nlm Unique ID: 100892005 Medline TA: J Acquir Immune Defic Syndr Country: United States |
Other Details:
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Languages: eng Pagination: 111-6 Citation Subset: IM; X |
Affiliation:
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INSERM U687, 16 avenue Paul Vaillant-Couturier, 94804 Villejuif, France. bertran.auvert@uvsq.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Circumcision, Male Follow-Up Studies Genotype HIV Infections / epidemiology*, virology Humans Incidence Longitudinal Studies Male Papillomaviridae / genetics, isolation & purification* Papillomavirus Infections / diagnosis*, virology Prevalence South Africa / epidemiology Young Adult |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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