| Association of OGG1 Ser326Cys polymorphism with colorectal cancer risk: a meta-analysis. | |
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MedLine Citation:
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PMID: 21695387 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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INTRODUCTION: 8-Oxoguanine DNA glycosylase 1 (OGG1), a key protein involved in the base excision repair pathway, can recognize and excise several lesions from oligodeoxynucleotides with single DNA damage. A C/G polymorphism at 1,245 bp (C1245G) in exon 7 of the OGG1 (Ser326Cys, rs1052133) is found to have a lower enzymatic activity. A variety of case-control studies have been published evaluating the association between OGG1 Ser326Cys polymorphism and colorectal cancer (CRC), though their conclusions were always contradictory. MATERIALS AND METHODS: This meta-analysis enrolled 12 studies to estimate the overall risk of OGG1 Ser326Cys polymorphism associated with CRC. The pooled odds ratios (ORs) were performed for codominant model (Cys/Cys versus Ser/Ser; Ser/Cys versus Ser/Ser), dominant model (Ser/Cys + Cys/Cys versus Ser/Ser) and recessive model (Cys/Cys versus Ser/Cys + Ser/Ser). RESULTS: No significant associations were found for Cys/Cys versus Ser/Ser (OR = 1.19, 95% confidence interval (CI) 0.92-1.53), Ser/Cys versus Ser/Ser (OR = 1.04, 95% CI 0.95-1.13), Ser/Cys + Cys/Cys versus Ser/Ser (OR = 1.06, 95% CI 0.98-1.16) and Cys/Cys versus Ser/Cys + Ser/Ser (OR = 1.11, 95% CI 0.90-1.38); moreover, in the stratified analyses, no significantly increased risk was found for all genetic models. CONCLUSIONS: Our meta-analysis suggests that the OGG1 Ser326Cys polymorphism is not associated with CRC risk. |
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Authors:
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Ying Zhang; Bang-Shun He; Yu-Qin Pan; Ye-Qiong Xu; Shu-Kui Wang |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-6-22 |
Journal Detail:
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Title: International journal of colorectal disease Volume: - ISSN: 1432-1262 ISO Abbreviation: - Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-6-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8607899 Medline TA: Int J Colorectal Dis Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Clinical Laboratory, Traditional Chinese Medicine Hospital of Kunshan, Kunshan, 215300, Jiangsu Province, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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