Document Detail


Association of N-Acetylaspartate and Cerebrospinal Fluid Aβ42 in Dementia.
MedLine Citation:
PMID:  21841259     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The interplay of amyloid and mitochondrial function is considered crucial in the pathophysiology of Alzheimer's disease (AD). We tested the association of the putative marker of mitochondrial function N-acetylaspartate (NAA) as measured by proton magnetic resonance spectroscopy within the medial temporal lobe and cerebrospinal fluid amyoid-β42 (Aβ42), total Tau and pTau181. 109 patients were recruited in a multicenter study (40 mild AD patients, 14 non-AD dementia patients, 29 mild cognitive impairment (MCI) AD-type patients, 26 MCI of non-AD type patients). NAA correlated with Aβ42 within the AD group. Since the NAA concentration is coupled to neuronal mitochondrial function, the correlation between NAA and Aβ42 may reflect the interaction between disrupted mitochondrial pathways and amyloid production.
Authors:
Frank Jessen; Piotr Lewczuk; Okan Gür; Wolfgang Block; Gabriele Ende; Lutz Frölich; Thilo Hammen; Sönke Arlt; Johannes Kornhuber; Thomas Kucinski; Julius Popp; Oliver Peters; Wolfgang Maier; Frank Träber; Jens Wiltfang
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-8-12
Journal Detail:
Title:  Journal of Alzheimer's disease : JAD     Volume:  -     ISSN:  1875-8908     ISO Abbreviation:  -     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-8-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9814863     Medline TA:  J Alzheimers Dis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Psychiatry, University of Bonn, Bonn, Germany German Centre for Neurodegenerative Diseases, Bonn, Germany.
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