| Association of monocyte chemotactic protein-1 and CC chemokine receptor 2 gene variants with preeclampsia. | |
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MedLine Citation:
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PMID: 20726788 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Preeclampsia complicates 10% of pregnancies in developing countries. It is one of the leading causes of maternal and fetal/neonatal mortality and morbidity worldwide. It has been suggested that maladaptation of the maternal immune response during pregnancy might be a causal factor for preeclampsia. According to immune maladaptation hypothesis, preeclampsia is due to an inappropriate regulation of normally Th2-deviated maternal immune responses, leading to a shift toward harmful Th1 immunity. Several studies indicate that monocyte chemotactic protein-1 (MCP-1) and CC chemokine receptor 2 (CCR2) are involved in Th1 and Th2 immunity. In this study, we investigated the association between MCP-1 A-2518G and CCR2-V64I polymorphisms and preeclampsia. One hundred eighty preeclamptic pregnant women and 145 healthy controls were included in the study. We observed that in preeclamptic women, MCP-1 G: CCR2 Val haplotype was significantly higher when compared with other haplotypes. In conclusion, we stated that MCP-1 and CCR2 gene variants might be associated with preeclampsia. |
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Authors:
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Bedia Agachan; Rukset Attar; Elif Isbilen; Hulya Yilmaz Aydogan; Seyma Sozen; Figen Gurdol; Turgay Isbir |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research Volume: 30 ISSN: 1557-7465 ISO Abbreviation: J. Interferon Cytokine Res. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9507088 Medline TA: J Interferon Cytokine Res Country: United States |
Other Details:
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Languages: eng Pagination: 673-6 Citation Subset: IM |
Affiliation:
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Department of Molecular Medicine, Institute for Experimental Medicine Research, Istanbul University, Istanbul, Turkey. agachanb@yahoo.com |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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