| Association of Masked Hypertension and Left Ventricular Remodeling With the Hypertensive Response to Exercise. | |
| | |
MedLine Citation:
|
PMID: 21525966 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
BackgroundA hypertensive response to exercise (HRE; defined as normal clinic blood pressure (BP) and exercise systolic BP (SBP) ≥210 mm Hg in men or ≥190 mm Hg in women, or diastolic BP (DBP) ≥105 mm Hg) independently predicts mortality. The mechanisms remain unclear but may be related to masked hypertension. This study aimed to assess the prevalence of masked hypertension and its association with cardiovascular risk factors, including left ventricular (LV) mass, in patients with a HRE.MethodsComprehensive clinical and echocardiographic evaluation (including central BP, aortic pulse wave velocity by tonometry) and 24-h ambulatory BP monitoring (ABPM) were performed in 72 untreated patients with HRE (aged 54 ± 9 years; 60% male; free from coronary artery disease confirmed by exercise stress echocardiography). Masked hypertension was defined according to guidelines as daytime ABPM ≥135/85 mm Hg and clinic BP <140/90 mm Hg.ResultsMasked hypertension was present in 42 patients (58%). These patients had higher LV mass index (41.5 ± 8.7g/m(2.7) vs. 35.9±8.5g/m(2.7); P = 0.01), LV relative wall thickness (RWT; 0.42 ± 0.09 vs. 0.37 ± 0.06; P = 0.004) and exercise SBP (222 ± 17 mm Hg vs. 212±14 mm Hg; P = 0.01), but no significant difference in aortic pulse wave velocity or central pulse pressure (P > 0.05 for both). The strongest independent determinant of LV mass index was the presence of masked hypertension (unstandardized β = 5.6; P = 0.007), which was also independently related to LV RWT (unstandardized β = 0.04; P = 0.03).ConclusionsMasked hypertension is highly prevalent in HRE patients with a normal resting office BP and is associated with increased LV mass index and RWT. Clinicians should consider measuring ABPM or home BP in HRE patients.American Journal of Hypertension (2011). doi:10.1038/ajh.2011.75. |
| | |
Authors:
|
James E Sharman; James L Hare; Scott Thomas; Justin E Davies; Rodel Leano; Carly Jenkins; Thomas H Marwick |
Related Documents
:
|
3278626 - Ventricular receptors stimulate vasopressin release during hemorrhage. 12468256 - Effect of no synthase inhibition on cardiovascular and pulmonary dysfunction in a porci... 8957686 - Adenosine for reversal of hemorrhagic shock in rabbits. 7536056 - Use of nitric oxide synthase inhibitors as a novel treatment for septic shock. 7866466 - Association between reduced lymphocyte beta-adrenergic receptors and left ventricular d... 9988356 - Intradialytic hypotension in relation to pre-existent autonomic dysfunction in hemodial... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-4-28 |
Journal Detail:
|
Title: American journal of hypertension Volume: - ISSN: 1879-1905 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
|
Created Date: 2011-4-28 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8803676 Medline TA: Am J Hypertens Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
1] Menzies Research Institute, University of Tasmania, Hobart, Australia [2] Department of Medicine, The University of Queensland, Brisbane, Australia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Home and Ambulatory Blood Pressure to Identify White Coat and Masked Hypertension in the Pediatric P...
Next Document: Management of Blood Pressure in Patients With Diabetes.