Document Detail

Association of MTHFR C677T and SHMT(1) C1420T with susceptibility to ESCC and GCA in a high incident region of Northern China.
MedLine Citation:
PMID:  17206530     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess the association between the C to T transition in the methylenetetrahydro folate reductase gene (MTHFR C677T) and the C to T transition in the serine hydroxymethyltransferase ( 1 )gene (SHMT ( 1 ) C1420T) and the increased risk of carcinogenesis of esophageal squamous cell carcinoma (ESCC) and gastric cardia adenocarcinoma (GCA) in a population of high incident region of Northern China. METHODS: The polymorphisms were genotyped by polymerase chain reaction-restriction fragment length polymorphism and PCR-confronting two-pair primers analysis respectively among 1051 cancer patients (584 ESCC and 467 GCA) and 540 healthy controls. RESULTS: The MTHFR 677T/T genotype significantly increased susceptibility to both ESCC and GCA compared with the C/C genotype, the adjusted OR was 2.13 (95% CI = 1.50-3.02) and 1.28 (95% CI = 1.07-1.53, respectively. For the SHMT ( 1 ) C1420T polymorphism, the C/C genotype was significantly associated with the increased risk of ESCC and GCA, compared with the C/T genotype (the adjusted OR = 1.43 and 1.35, 95% CI = 1.02-2.00 and 1.11-1.63, respectively). The interactive influence of the MTHFR and SHMT ( 1 ) polymorphisms in the risk of ESCC and GCA was also observed. CONCLUSION: The association between the MTHFR C677T and SHMT ( 1 ) C1420T polymorphisms and the risk of ESCC and GCA was demonstrated.
Yimin Wang; Wei Guo; Yutong He; Zhifeng Chen; Denggui Wen; Xiufeng Zhang; Na Wang; Yan Li; Hui Ge; Jianhui Zhang
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-01-06
Journal Detail:
Title:  Cancer causes & control : CCC     Volume:  18     ISSN:  0957-5243     ISO Abbreviation:  Cancer Causes Control     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-02-07     Completed Date:  2007-05-15     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  9100846     Medline TA:  Cancer Causes Control     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  143-52     Citation Subset:  IM    
Hebei Cancer Institute, Hebei Medical University, Jiankanglu 12, Shijiazhuang, 050011, Hebei Province, China.
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MeSH Terms
Adenocarcinoma / genetics*
Case-Control Studies
China / epidemiology
Esophageal Neoplasms / genetics*
Genetic Predisposition to Disease / genetics
Genetic Testing
Glycine Hydroxymethyltransferase / genetics*
Methylenetetrahydrofolate Reductase (NADPH2) / genetics*
Middle Aged
Neoplasms, Squamous Cell / genetics*
Polymorphism, Single Nucleotide / genetics
Stomach Neoplasms / genetics*
Reg. No./Substance:
EC Reductase (NADPH2); EC Hydroxymethyltransferase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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