| Association of MRI metrics and cognitive impairment in radiologically isolated syndromes. | |
| | |
MedLine Citation:
|
PMID: 22262744 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
OBJECTIVE:To evaluate cognitive changes in a cohort of radiologically isolated syndromes (RIS) suggestive of multiple sclerosis (MS) and to assess their relationship with quantitative magnetic resonance (MR) measures such as white matter (WM), lesion loads, and cerebral atrophy. METHODS:We assessed the cognitive performance in a group of 29 subjects with RIS recruited from 5 Italian MS centers and in a group of 26 patients with relapsing-remitting MS (RRMS). A subgroup of 19 subjects with RIS, 26 patients with RRMS, and 21 healthy control (HC) subjects also underwent quantitative MR assessments, which included WM T1 and T2 lesion volumes and global and cortical brain volumes. RESULTS:Cognitive impairment of the same profile as that of RRMS was found in 27.6% of our subjects with RIS. On MR scans, we found comparable levels of lesion loads and brain atrophy in subjects with RIS and well-established RRMS. In subjects with RIS, high T1 lesion volume (ρ = 0.526, p = 0.025) and low cortical volume (ρ = -0.481, p = 0.043) were associated with worse cognitive performance. CONCLUSIONS:These findings emphasize the importance of including accurate neuropsychological testing and quantitative MR metrics in subjects with RIS suggestive of MS. They can provide a better characterization of these asymptomatic subjects, potentially useful for diagnostic and therapeutic decisions. |
| | |
Authors:
|
M P Amato; B Hakiki; B Goretti; F Rossi; M L Stromillo; A Giorgio; M Roscio; A Ghezzi; L Guidi; M L Bartolozzi; E Portaccio; N De Stefano; |
Related Documents
:
|
19021824 - Carotid body tumors: advantages of contrast ultrasound investigation. 16790904 - Development of methods for body composition studies. 22121694 - Transition of the magnetotransport in a co-tbn system. 16099774 - Short-term changes in sedentary behaviour during adolescence: project stil (sedentary t... 20616784 - Rapid homogeneous detection of biological assays using magnetic modulation biosensing s... 16024964 - Solitary splenic metastasis in a patient with a malignant melanoma diagnosed with f-18-... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-1-18 |
Journal Detail:
|
Title: Neurology Volume: - ISSN: 1526-632X ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
|
Created Date: 2012-1-20 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0401060 Medline TA: Neurology Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
From the Department of Neurology (M.P.A., B.H., B.B., E.P.), University of Florence, Florence; Department of Neurology (F.R., M.L.S., A.G., N.D.), University of Siena, Siena; Multiple Sclerosis Centre (M.R., A.G.), Hospital of Gallarate, Gallarate; and Neurology Unit (L.G., M.L.B.), Hospital of Empoli, Florence, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Antigen microarrays identify CNS-produced autoantibodies in RRMS.
Next Document: Paradoxical worsening of gait with levodopa in Parkinson disease.