| Association of MR relaxation and cartilage deformation in knee osteoarthritis. | |
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MedLine Citation:
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PMID: 22161783 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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We assessed the relationship between cartilage MR relaxation times and biomechanical response of tibiofemoral articular cartilage to physiological loading in healthy subjects and patients with osteoarthritis (OA). Female subjects above 40 years of age with (N(1) = 20) and without (N(2) = 10) OA were imaged on a 3T MR scanner using a custom made loading device. MR images were acquired with the knee flexed at 20° with and without a compressive load of 50% of the subject's bodyweight. The subjects were categorized based on the clinical MRI scoring of medial and lateral cartilage surfaces. Data were stratified twice into two equal groups (low and high) at the median value of T(1ρ) and T(2) relaxation time. The change in contact area and cartilage deformation was measured within these groups. Paired Student's t-test (α = 0.05) was used to analyze the effect of loading on contact area and deformation. The average area of the contact region in the medial compartment was significantly higher in OA subjects compared with normal subjects in both unloaded (314 ± 112 mm(2) vs. 227 ± 106 mm(2) , p = 0.023) and loaded (425 ± 128 mm(2) vs. 316 ± 107 mm(2) , p = 0.01) conditions. The overall relative change of cartilage thickness in the medial compartment was significantly higher than the lateral compartment (-5.3 ± 9.9% vs. -1.9 ± 9.2%, p = 0.042). When cartilage was divided into deep and superficial layers, superficial layers showed higher changes in relaxation time (T(1ρ) and T(2) ) than the changes in relaxation time of whole cartilage (Normal: 12.5% vs. 6.9%; OA: 10.9% vs. 4.6%). The average T(1ρ) and T(2) times, change in area of contact region, and change in cartilage thickness in subjects with OA were higher when compared to normal subjects. This study provides support for a relationship between the mechanical response of cartilage to physiological loading (cartilage-on-cartilage contact area and cartilage deformation) and MR relaxation times (T(1ρ) and T(2) ) in both OA patients and normal subjects. © 2011 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res. |
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Authors:
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K Subburaj; R B Souza; C Stehling; B T Wyman; M-P Le Graverand-Gastineau; T M Link; X Li; S Majumdar |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-7 |
Journal Detail:
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Title: Journal of orthopaedic research : official publication of the Orthopaedic Research Society Volume: - ISSN: 1554-527X ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8404726 Medline TA: J Orthop Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Orthopaedic Research Society. |
Affiliation:
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Musculoskeletal and Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California, San Francisco, QB3, Suite 203, 1700 4th Street, San Francisco 94158, California. subburaj@radiology.ucsf.edu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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