Document Detail


Association of long-term air pollution with ventricular conduction and repolarization abnormalities.
MedLine Citation:
PMID:  21918454     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Short-term exposure to air pollution may affect ventricular repolarization, but there is limited information on how long-term exposures might affect the surface ventricular electrocardiographic (ECG) abnormalities associated with cardiovascular events. We carried out a study to determine whether long-term air pollution exposure is associated with abnormalities of ventricular repolarization and conduction in adults without known cardiovascular disease.
METHODS: A total of 4783 participants free of clinical cardiovascular disease in the Multi-Ethnic Study of Atherosclerosis underwent 12-lead ECG examinations, cardiac-computed tomography, and calcium scoring, as well as estimation of air pollution exposure using a finely resolved spatiotemporal model to determine long-term average individual exposure to fine particulate matter (PM(2.5)) and proximity to major roadways. We assessed ventricular electrical abnormalities including presence of QT prolongation (Rautaharju QTrr criteria) and intraventricular conduction delay (QRS duration >120 milliseconds). We used logistic regression to determine the adjusted relationship between air pollution exposures and ECG abnormalities.
RESULTS: A 10-μg/m³ increase in estimated residential PM(2.5) was associated with an increased odds of prevalent QT prolongation (adjusted odds ratio [OR] = 1.6 [95% confidence interval (CI) = 1.2-2.2]) and intraventricular conduction delay (1.7 [1.0-2.6]), independent of coronary-artery calcium score. Living near major roadways was not associated with ventricular electrical abnormalities. No evidence of effect modification by traditional risk factors or study site was observed.
CONCLUSIONS: This study demonstrates an association between long-term exposure to air pollution and ventricular repolarization and conduction abnormalities in adults without clinical cardiovascular disease, independent of subclinical coronary arterial calcification.
Authors:
Victor C Van Hee; Adam A Szpiro; Ronald Prineas; Jonathan Neyer; Karol Watson; David Siscovick; Sung Kyun Park; Joel D Kaufman
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Epidemiology (Cambridge, Mass.)     Volume:  22     ISSN:  1531-5487     ISO Abbreviation:  Epidemiology     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-10-05     Completed Date:  2012-03-08     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  9009644     Medline TA:  Epidemiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  773-80     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Air Pollution / adverse effects*
Arrhythmias, Cardiac / chemically induced*
Chi-Square Distribution
Confidence Intervals
Electrocardiography
Environmental Exposure / adverse effects
Female
Heart / drug effects,  physiopathology,  radiography
Heart Ventricles / drug effects,  physiopathology
Humans
Logistic Models
Male
Middle Aged
Odds Ratio
Particulate Matter / adverse effects
Tomography, X-Ray Computed
Grant Support
ID/Acronym/Agency:
K23 ES019575/ES/NIEHS NIH HHS; K23 ES019575-01/ES/NIEHS NIH HHS; K23 ES019575-02/ES/NIEHS NIH HHS; K23 ES019575-03/ES/NIEHS NIH HHS; K23ES019575/ES/NIEHS NIH HHS; K24 ES013195/ES/NIEHS NIH HHS; K24 ES013195-08/ES/NIEHS NIH HHS; K24ES013195/ES/NIEHS NIH HHS; N01 HC095159/HC/NHLBI NIH HHS; N01 HC095160/HC/NHLBI NIH HHS; N01 HC095161/HC/NHLBI NIH HHS; N01 HC095162/HC/NHLBI NIH HHS; N01 HC095163/HC/NHLBI NIH HHS; N01 HC095164/HC/NHLBI NIH HHS; N01 HC095165/HC/NHLBI NIH HHS; N01 HC095169/HC/NHLBI NIH HHS; N01-HC-95159/HC/NHLBI NIH HHS; N01-HC-95160/HC/NHLBI NIH HHS; N01-HC-95161/HC/NHLBI NIH HHS; N01-HC-95162/HC/NHLBI NIH HHS; N01-HC-95163/HC/NHLBI NIH HHS; N01-HC-95164/HC/NHLBI NIH HHS; N01-HC-95165/HC/NHLBI NIH HHS; N01-HC-95169/HC/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Particulate Matter
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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