Document Detail

The Association of Liver Enzymes with Biomarkers of Subclinical Myocardial Damage and Structural Heart Disease.
MedLine Citation:
PMID:  25433159     Owner:  NLM     Status:  Publisher    
BACKGROUND AND AIMS: Patients with non-alcoholic fatty liver disease (NAFLD) are thought to be at increased risk of cardiovascular morbidity and mortality. However, the relationships NAFLD to subclinical myocardial injury or structural heart disease are unknown.
METHODS: We conducted a cross-sectional analysis of 8668 participants from the Atherosclerosis Risk in the Communities (ARIC) Study without clinical evidence of cardiovascular disease. We used levels of liver enzymes (Alanine aminotrasferase [ALT], Aspartate aminotranferase [AST] and Gamma-glutamyl transpeptidase [GGT]), in the context of no history of elevated alcohol consumption as non-invasive surrogates of NAFLD. We used highly sensitive cardiac troponin T (hs-cTnT) and n-terminal pro-Brain natriuretic peptide (NT-proBNP) as biomarkers of myocardial damage and function.
RESULTS: In this population-based study (mean age 63 years, 60% women, 78% white), higher levels of ALT, AST and GGT, even within the normal range, were significantly and independently associated with detectable (hs-cTnT>3 ng/L) and elevated (hs-cTnT⩾14 ng/L) concentrations of hs-TnT. The adjusted odds ratios (95% confidence interval) for elevated liver enzymes (vs normal levels) with elevated hs-cTnT were: 1.65 (1.28-2.14) for ALT, 1.90 (1.36-2.68) for AST, and 1.55 (1.13-2.12) for GGT. Furthermore, there was evidence for inverse associations of ALT and AST with NT-proBNP.
CONCLUSION: Our results suggest that elevated liver enzymes in the absence of elevated alcohol consumption, may be associated with subclinical myocardial injury. The inverse association between NT-proBNP and ALT and AST support the recently described metabolic role of natriuretic peptides.
Mariana Lazo; Jonathan Rubin; Jeanne M Clark; Josef Coresh; Andrea L C Schneider; Chiadi Ndumele; Ron C Hoogeveen; Christie M Ballantyne; Elizabeth Selvin
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-11-26
Journal Detail:
Title:  Journal of hepatology     Volume:  -     ISSN:  1600-0641     ISO Abbreviation:  J. Hepatol.     Publication Date:  2014 Nov 
Date Detail:
Created Date:  2014-11-29     Completed Date:  -     Revised Date:  2014-11-30    
Medline Journal Info:
Nlm Unique ID:  8503886     Medline TA:  J Hepatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014. Published by Elsevier B.V.
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