Document Detail

Association of late-preterm birth with asthma in young children: practice-based study.
MedLine Citation:
PMID:  21911345     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate the association of late-preterm birth with asthma severity among young children.
METHODS: A retrospective cohort study was performed with electronic health record data from 31 practices affiliated with an academic medical center. Participants included children born in 2007 at 34 to 42 weeks of gestation and monitored from birth to 18 months. We used multivariate logistic or Poisson models to assess the impact of late-preterm (34-36 weeks) and low-normal (37-38 weeks) compared with term (39-42 weeks) gestation on diagnoses of asthma and persistent asthma, inhaled corticosteroid use, and numbers of acute respiratory visits.
RESULTS: Our population included 7925 infants (7% late-preterm and 21% low-normal gestation). Overall, 8.3% had been diagnosed with asthma by 18 months. Compared with term gestation, late-preterm gestation was associated with significant increases in persistent asthma diagnoses (adjusted odds ratio [aOR]: 1.68), inhaled corticosteroid use (aOR: 1.66), and numbers of acute respiratory visits (incidence rate ratio: 1.44). Low-normal gestation was associated with increases in asthma diagnoses (aOR: 1.34) and inhaled corticosteroid use (aOR: 1.39).
CONCLUSION: Birth at late-preterm and low-normal gestational ages might be an important risk factor for the development of asthma and for increased health service use in early childhood.
Neera K Goyal; Alexander G Fiks; Scott A Lorch
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-09-12
Journal Detail:
Title:  Pediatrics     Volume:  128     ISSN:  1098-4275     ISO Abbreviation:  Pediatrics     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-03     Completed Date:  2011-11-30     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e830-8     Citation Subset:  AIM; IM    
MSCE, Children's Hospital of Philadelphia, 3535 Market St, Suite 1029, Philadelphia, PA 19104.
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MeSH Terms
Adrenal Cortex Hormones / therapeutic use
Anti-Asthmatic Agents / therapeutic use
Asthma / diagnosis,  drug therapy,  epidemiology*
Cohort Studies
Gestational Age
Infant, Newborn
Infant, Premature
Logistic Models
Multivariate Analysis
Poisson Distribution
Premature Birth*
Primary Health Care / utilization
Retrospective Studies
Risk Factors
Severity of Illness Index
Grant Support
Reg. No./Substance:
0/Adrenal Cortex Hormones; 0/Anti-Asthmatic Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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