| Association of LIPC and advanced age-related macular degeneration. | |
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MedLine Citation:
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PMID: 23348725 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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PurposeTo determine whether there is an association between hepatic lipase (LIPC) and age-related macular degeneration (AMD) in two independent Caucasian cohorts.MethodsA discovery cohort of 1626 patients with advanced AMD and 859 normal controls and a replication cohort of 2159 cases and 1150 controls were genotyped for two single-nucleotide polymorphisms (SNPs) in the promoter region of LIPC. The associations between the SNPs and AMD were examined by χ(2) tests.ResultsIn the discovery cohort, rs493258 and rs10468017 were both associated with advanced AMD (P=9.63E-3 and P=0.048, respectively). The association was corroborated in the replication cohort (P=4.48E-03 for rs493258 and P=0.015 for rs10468017). Combined analysis resulted in even more significant associations (P=1.21E-04 for rs493258 and P=1.67E-03 for rs10468017).ConclusionThe LIPC promoter variants rs493258 and rs10468017 were associated with advanced AMD in two independent Caucasian populations, confirming that LIPC polymorphisms may be a genetic risk factor for AMD in the Caucasian population.Eye advance online publication, 25 January 2013; doi:10.1038/eye.2012.276. |
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Authors:
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J Lee; J Zeng; G Hughes; Y Chen; S Grob; L Zhao; C Lee; M Krupa; J Quach; J Luo; J Zeng; X Wei; X Zhang; J Zhu; Y Duan; H Ferreyra; M Goldbaum; W Haw; P X Shaw; L Tang; K Zhang |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-1-25 |
Journal Detail:
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Title: Eye (London, England) Volume: - ISSN: 1476-5454 ISO Abbreviation: Eye (Lond) Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-1-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8703986 Medline TA: Eye (Lond) Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Ophthalmology and Shiley Eye Center and Institute for Genomic Medicine, University of California, San Diego, La Jolla, CA, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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