Document Detail


Association of LEP and ADIPOQ common variants with colorectal cancer in Mexican patients.
MedLine Citation:
PMID:  21263187     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Leptin and adiponectin are cytokines produced by adipose tissue with opposite effects on tumor growth: the former stimulate whereas the latter inhibit it. The objective was to analyze the association of LEP A19G and ADIPOQ+45 T/G and +276 G/T polymorphisms in Mexican patients with colorectal cancer (CRC). 68 unrelated patients with CRC (study group) and 102 blood donors (control group); all subjects were Mestizos from western Mexico. The polymorphisms were established by PCR-RFLP on DNA samples obtained from peripheral blood. The LEP A19G polymorphism showed significant differences between CRC patients and control group (p= 0.01 for G/A genotype and p= 0.02 for the recessive model G/G +G/A); yet, in the analysis stratified by gender, this difference remained significant only in males. The ADIPOQ polymorphisms did not shown any significant differences. Our results suggest that the A19G LEP polymorphism is associated with CRC in Mexican patients.
Authors:
Miriam Partida-Pérez; María de la Luz Ayala-Madrigal; Jorge Peregrina-Sandoval; Nelly Macías-Gómez; José Moreno-Ortiz; Evelia Leal-Ugarte; Mario Cárdenas-Meza; Manuel Centeno-Flores; Víctor Maciel-Gutiérrez; Enrique Cabrales; Sergio Cervantes-Ortiz; Melva Gutiérrez-Angulo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cancer biomarkers : section A of Disease markers     Volume:  7     ISSN:  1875-8592     ISO Abbreviation:  Cancer Biomark     Publication Date:  2010  
Date Detail:
Created Date:  2011-01-25     Completed Date:  2011-05-04     Revised Date:  2012-04-09    
Medline Journal Info:
Nlm Unique ID:  101256509     Medline TA:  Cancer Biomark     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  117-21     Citation Subset:  IM    
Affiliation:
Instituto de Genética Humana, CUCS, U de G. Sierra Mojada no. 950, Guadalajara, Jalisco, México.
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MeSH Terms
Descriptor/Qualifier:
Adiponectin / genetics
Carcinoma / epidemiology,  genetics*
Colorectal Neoplasms / epidemiology,  genetics*
Female
Gene Frequency
Genetic Variation
Genome-Wide Association Study
Humans
Leptin / genetics*
Male
Mexico / epidemiology
Middle Aged
Polymorphism, Restriction Fragment Length / physiology
Polymorphism, Single Nucleotide
Chemical
Reg. No./Substance:
0/ADIPOQ protein, human; 0/Adiponectin; 0/Leptin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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