Document Detail


Association of Known Loci with Lipid Levels Among Children and Prediction of Dyslipidemia in Adults.
MedLine Citation:
PMID:  21984478     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: -Recent genome-wide association study has found 95 distinct genetic loci associated with high-density (HDL-C) and low-density (LDL-C) lipoprotein cholesterol, total cholesterol (TC), and triglycerides (TG) using adult samples. It is not known if these variants are associated with lipid levels in children and adolescents, and if the genetic risk score (GRS) based on these variants could improve adulthood dyslipidemia prediction over the childhood lipid measurements. METHODS AND RESULTS: -We used 2443 participants of the Cardiovascular Risk in Young Finns study cohort with up to five measurements of serum lipids taken between ages 3 and 45 to estimate the effect of individual SNPs and the GRSs on lipids. The GRSs were strongly associated with lipids in all age groups (1.5 x 10(-20)<P<8.7 x 10(-12) for HDL-C, 3.5 x 10(-27)<P<5.6 x 10(-09) for LDL-C, 2.0 x 10(-25)<P<5.2 x 10(-09) for TC, and 4.1 x 10(-20)<P<8.4 x 10(-05) for TG). Jointly, the lipid loci explained 11.8-26.7 % of the total variance in lipids among 3-6 year old children and the proportion dropped over age, except for TG. The discrimination of adult hypertriglyceridemia improved when GRS was added to childhood lipid measurement (C statistic = 0.04, p=0.01). CONCLUSIONS: -Previously identified lipid loci are associated with lipid levels in children and adolescents and explain up to more than two times of the lipid variation in children compared to adults. The TG-GRS improves the risk discrimination over childhood lipid measurement for adult hypertriglyceridemia.
Authors:
Emmi Tikkanen; Tarja Tuovinen; Elisabeth Widén; Terho Lehtimäki; Jorma Viikari; Mika Kähönen; Leena Peltonen; Olli T Raitakari; Samuli Ripatti
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-10-7
Journal Detail:
Title:  Circulation. Cardiovascular genetics     Volume:  -     ISSN:  1942-3268     ISO Abbreviation:  -     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101489144     Medline TA:  Circ Cardiovasc Genet     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
1 FIMM, University of Helsinki & National Institute for Health and Welfare, Helsinki, Finland;
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