| Association of KIR genotype with susceptibility to HLA-B27-positive ankylosing spondylitis. | |
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MedLine Citation:
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PMID: 22744805 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE: Recent studies have explored the role of killer cell immunoglobulin-like receptors (KIRs) in chronic autoimmune diseases. The purpose of this study was to demonstrate whether KIR genes contribute to the pathogenesis of ankylosing spondylitis (AS) in Chinese populations. METHODS: Sixteen KIR genes were genotyped from 60 unrelated patients with AS and 60 HLA-B27-positive matched healthy controls by PCR-SSP. The frequencies of the KIR alleles and genotypes in the AS and control groups were assessed by the χ (2) test. RESULTS: Our results showed that the frequency of the activator receptor KIR3DS1 gene in the AS group was significantly increased compared to the controls (χ (2) = 5.263, P = 0.006, OR = 3.059, 95 % CI = 1.357-6.896). Moreover, the frequency of the KIR3DL1/3DS1 genotype was greater in the AS group than in the control group (P = 0.039, OR = 3.059, 95 % CI = 1.357-6.896). In contrast, the frequency of the no KIR3DL1/no 3DS1 genotype was lower in patients with AS compared with the controls (P = 0.032, OR = 0.110, 95 % CI = 0.013-0.911). CONCLUSION: KIR3DS1, in addition to HLA-B27, may play an important independent role in the pathogenesis of AS in the Chinese population. |
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Authors:
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Sheng Wang; Guixing Li; Rui Ge; Zhenhua Duan; Zhen Zeng; Tianchen Zhang; Jing Gao; Ting Yang; Si Liu; Shanshan Wu; Dazhi Fan; Shengqian Xu; Jianhua Xu; Li Zhang; Zongwen Shuai; Dongqing Ye; Yanfeng Zou; Faming Pan |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-6-29 |
Journal Detail:
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Title: Modern rheumatology / the Japan Rheumatism Association Volume: - ISSN: 1439-7609 ISO Abbreviation: - Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-6-29 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100959226 Medline TA: Mod Rheumatol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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