| Association of interleukin-10-1082 g/g genotype with lower mortality of acute respiratory distress syndrome in a chinese population. | |
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MedLine Citation:
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PMID: 21138342 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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We investigate whether interleukin-10 (IL-10)-1082 G/G genotype is associated with the mortality rate of acute respiratory distress syndrome (ARDS) in a hospital-based case-control study in China conducted on 314 patients with ARDS and 210 controls admitted to an intensive care unit for sepsis, trauma, aspiration, or massive transfusions. IL-10-1082 promoter polymorphisms were analyzed with polymerase chain reaction amplification followed by restriction fragment length polymorphism. Mortality was recorded if it occurred within 30 days from admission. The -1082G/G genotype was associated with lower frequency of ARDS (odds ratios = 0.51; 95% confidence intervals: 0.34-0.76; p = 0.001), and in patients with ARDS, it was associated with lower mortality within 30 days (odds ratios = 0.44; 95% confidence intervals: 0.25-0.76; p = 0.003) than in controls. We conclude that IL-10-1082 G/G genotype is associated with a decreased rate development of ARDS and mortality in this Chinese population. |
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Authors:
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Xiaodong Jin; Zhi Hu; Yan Kang; Chang Liu; Yongfang Zhou; Xiaodong Wu; Jin Liu; Mingxing Zhong; Chuanxing Luo; Lijing Deng; Yiyun Deng; Xiaoqi Xie; Zhongwei Zhang; Yan Zhou; Xuelian Liao |
Publication Detail:
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Type: Journal Article Date: 2010-12-07 |
Journal Detail:
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Title: Genetic testing and molecular biomarkers Volume: 15 ISSN: 1945-0257 ISO Abbreviation: Genet Test Mol Biomarkers Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-03-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101494210 Medline TA: Genet Test Mol Biomarkers Country: United States |
Other Details:
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Languages: eng Pagination: 203-6 Citation Subset: IM |
Affiliation:
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1 Intensive Care Unit, West China Hospital, Sichuan University , Chengdu, China . |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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