| Association of Inhibitors of Gastric Acid Secretion and Higher Incidence of Necrotizing Enterocolitis in Preterm Very Low-Birth-Weight Infants. | |
| | |
MedLine Citation:
|
PMID: 23359235 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Background Inhibitors of gastric acid (IGA) are used for upper gastrointestinal bleeding or gastroesophageal reflux in preterm infants. The resultant increase in gastric pH may enhance the growth of pathogens and increase the risk of necrotizing enterocolitis (NEC). Our systematic review examined the association between IGA and NEC in preterm infants.Methods Standard methodology of systematic reviews was followed. PubMed, Embase, Cochrane, and Cumulative Index to Nursing and Allied Health Literature (CINAHL) databases were searched in August 2012.Results One case-control and one prospective cohort study (n = 11,346), both evaluating H2-blockers as IGA, were included. Meta-analysis showed a significant association between NEC and IGA (odds ratio [OR]: 1.78, 95% confidence interval [CI]: 1.4, 2.27, p < 0.00001). The prospective cohort study found higher incidence of infection (sepsis, pneumonia, urinary tract infection) with IGA (37.4% versus 9.8%, OR: 5.5, 95% CI: 2.9 to 10.4, p < 0.001).Conclusions Exposure to H2 receptor antagonists may be associated with increased risk of NEC and infections in preterm infants. |
| | |
Authors:
|
Kiran More; Gayatri Athalye-Jape; Shripada Rao; Sanjay Patole |
Related Documents
:
|
7576885 - High frequency oscillation in newborn infants with respiratory failure. 9735895 - Measuring human ventilation for apnoea detection using an optical encoder. 10516395 - Early (4-7 days of age) dexamethasone therapy for prevention of chronic lung disease in... 23633315 - Prophylactic systemic antifungal agents to prevent mortality and morbidity in very low ... 11083375 - Non-nutritive sucking by infants exposed to pethidine in utero. 11109135 - An unfortunate family: terminal illness and the altering of the attachment bond. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2013-1-28 |
Journal Detail:
|
Title: American journal of perinatology Volume: - ISSN: 1098-8785 ISO Abbreviation: Am J Perinatol Publication Date: 2013 Jan |
Date Detail:
|
Created Date: 2013-1-29 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8405212 Medline TA: Am J Perinatol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA. |
Affiliation:
|
Department of Neonatal Paediatrics, Princess Margaret Hospital, Perth, Western Australia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Changes in Care Associated with the Introduction of a Postpartum Hemorrhage Patient Safety Program.
Next Document: A Randomized Controlled Trial of Plastic Drape for Prevention of Hypothermia during Umbilical Cathet...