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Association of Inflammation, Myocardial Fibrosis, and Cardiac Remodeling in Patients with Mild Aortic Stenosis as Assessed by Biomarkers and Echocardiography.
MedLine Citation:
PMID:  24471798     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The aim of this study is to investigate the relationship of inflammation, myocardial fibrosis, and cardiac remodeling in patients with mild aortic stenosis (AS) as assessed by biomarkers and echocardiography. We consecutively evaluated 32 patients with mild AS and thirty age and gender matched, healthy individuals with normal aortic valves were recruited as control subjects for this study. Baseline echocardiography showed that left ventricular mass index (LVMI, 111.3 ± 26.9 g/m(2) vs. 94.5 ± 18.2 g/m(2) , p-value = 0.006) and left atrial volume index (LAVI, 27.5 ± 9.0 mm(3) /mm(2) vs. ± 5.2 mm(3) /mm(2) , p-value = 0.005) were significantly higher in patients with mild AS. Left atrial enlargement (LAVI >33 mm(3) /mm(2) , 32.4% vs. 3.3%, p-value = 0.003) and elevated left ventricular filling pressure (E/e' >15, 50.0% vs. 23.3%, p-value=0.036) were higher in patients with mild AS. In the patients with mild AS, stepwise, multivariate linear regression analysis showed that the left ventricular end diastolic volume index (LVEDVI) was independently associated with matrix metalloproteinase (MMP)-1(β= 0.371, p-value=0.015), aortic valve mean pressure gradient (AVMPG) was independently associated with MMP-2 (β= 0.19, p-value=0.019), transforming growth factor (TGF)-β (β=0.95, p-value<0.001) and interleukin (IL)-1(β= 0.17, p-value=0.019) were independently associated with MMP-2, and IL-1 was independently associated with tissue inhibitor of matrix metalloproteinase (TIMP)-1 (β= 0.68, p-value=0.001). Myocardial fibrosis in mild AS is independently associated with three factors: LV volume overload, aortic valve pressure overload, and inflammation. This article is protected by copyright. All rights reserved.
Authors:
Ji Young Park; Sung Kee Ryu; Jae Woong Choi; Kim Min Ho; Jin Hyun Jun; Seung-Woon Rha; Seong-Mi Park; Hyo Jeong Kim; Byoung Geol Choi; Yung-Kyun Noh; Seungwhan Kim
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-1-28
Journal Detail:
Title:  Clinical and experimental pharmacology & physiology     Volume:  -     ISSN:  1440-1681     ISO Abbreviation:  Clin. Exp. Pharmacol. Physiol.     Publication Date:  2014 Jan 
Date Detail:
Created Date:  2014-1-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0425076     Medline TA:  Clin Exp Pharmacol Physiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
This article is protected by copyright. All rights reserved.
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