Document Detail


Association of IL-6 gene polymorphisms and COPD in a Spanish population.
MedLine Citation:
PMID:  18693004     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Interleukin-6 (IL-6) is a potential mediator of systemic effects of Chronic Obstructive Pulmonary Disease (COPD). In the present case-control study we investigated the association of promoter polymorphisms of this gene and COPD in a cohort of 191 patients, smokers without COPD (n=75) and a healthy control population (n=296). Besides spirometry, exercise capacity (6MWD, 6 min walking distance) and body mass index (BMI) were measured in COPD patients. Genotyping of the IL-6 polymorphisms at positions -174, -572 and -597 was performed. The -597G/A and -174G/C polymorphisms were not associated with the disease. However, the -572G/C polymorphism was significantly associated with COPD susceptibility under a dominant model of inheritance. The frequency of the genotypes containing the C allele was significantly lower in the COPD cases (9.9%) compared with the healthy control group (16.9%) and smokers (23.1%), (OR=0.46, p=0.032 and OR=0.28, p=0.012, respectively). The GCG (-597/-572/-174) haplotype was significantly associated with the disease (OR=0.37, p=0.022, COPD cases vs. healthy subjects and OR=0.17, p=0.011, COPD cases vs. smokers). Moreover, a borderline association was also found for the -572G allele and hypoxemia (PaO(2)<60 mmHg) (p=0.05). Our data suggest that the IL-6 -572C allele may confer a diminished risk of developing COPD.
Authors:
Elizabeth Córdoba-Lanús; Juan-Pablo de-Torres; Celeste López-Aguilar; María-Cristo Rodríguez-Pérez; Nicole Maca-Meyer; Angela Montejo-de-Garcini; Armando Aguirre-Jaime; Lina Pérez-Méndez; Ciro Casanova
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-08-09
Journal Detail:
Title:  Respiratory medicine     Volume:  102     ISSN:  1532-3064     ISO Abbreviation:  Respir Med     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-11-17     Completed Date:  2009-01-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8908438     Medline TA:  Respir Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  1805-11     Citation Subset:  IM    
Affiliation:
Research Unit, Hospital Universitario Nuestra Señora de Candelaria, Ctra. del Rosario s/n, Santa Cruz de Tenerife 38010, Spain. elizabeth-cordoba@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Case-Control Studies
Female
Genetic Markers
Genetic Predisposition to Disease
Genotype
Haplotypes
Humans
Interleukin-6 / genetics*
Male
Middle Aged
Polymorphism, Single Nucleotide*
Promoter Regions, Genetic / genetics
Pulmonary Disease, Chronic Obstructive / genetics*
Smoking / genetics
Chemical
Reg. No./Substance:
0/Genetic Markers; 0/Interleukin-6

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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