|Association of the HindIII and S447X polymorphisms in LPL gene with hypertension and type 2 diabetes in Mexican families.|
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|PMID: 23089926 Owner: NLM Status: MEDLINE|
|Lipoprotein lipase (LPL) is a key enzyme in lipid metabolism and is associated with obesity, dyslipidemias, hypertension (HTN) and type 2 diabetes mellitus (T2DM). LPL gene polymorphisms can be related with the development of cardiovascular risk factors. The present study was conducted to analyze the relationship of the HindIII and S447X polymorphisms in LPL gene with cardiovascular risk factors in Mexican families. The study population comprised ninety members of 30 Mexican families, in which an index case had obesity, were included in the study. We evaluated the body composition by bioelectrical impedance. Peripheral blood samples were collected to determine biochemical parameters. Screening for both polymorphisms was made by PCR-RFLPs. In the parents, both polymorphisms were in Hardy-Weinberg's equilibrium. We found that the genotype T/T of HindIII was associated with diastolic blood pressure ≥ 85 mmHg (OR=1.1; p=0.011), whereas the genotype C/C of S447X was associated with systolic blood pressure ≥ 130 mmHg (OR=1.2; p<0.001), diastolic blood pressure ≥ 85 mmHg (OR = 1.3; p< 0.001), T2DM (OR=1.3; p< 0.001) and with increase of total cholesterol (β =23.6 mg/mL; p=0.03). These data suggest that the HindIII and S447X LPL gene polymorphisms can confer susceptibility for the development of hypertension and T2DM in Mexican families.|
|Salvador Muñoz-Barrios; Iris Paola Guzmán-Guzmán; José Francisco Muñoz-Valle; Aralia Berenice Salgado-Bernabé; Lorenzo Salgado-Goytia; Isela Parra-Rojas|
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|Type: Journal Article|
|Title: Disease markers Volume: 33 ISSN: 1875-8630 ISO Abbreviation: Dis. Markers Publication Date: 2012|
|Created Date: 2012-12-11 Completed Date: 2013-05-20 Revised Date: 2013-12-11|
Medline Journal Info:
|Nlm Unique ID: 8604127 Medline TA: Dis Markers Country: Netherlands|
|Languages: eng Pagination: 313-20 Citation Subset: IM|
|APA/MLA Format Download EndNote Download BibTex|
Blood Pressure / genetics
Body Mass Index
Cholesterol / blood
Diabetes Mellitus, Type 2 / genetics*
Genetic Association Studies
Genetic Predisposition to Disease*
Hypertension / genetics*
Lipoprotein Lipase / genetics*
Polymorphism, Restriction Fragment Length*
Polymorphism, Single Nucleotide*
|97C5T2UQ7J/Cholesterol; EC 126.96.36.199/LPL protein, human; EC 188.8.131.52/Lipoprotein Lipase|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Journal ID (nlm-ta): Dis Markers
Journal ID (iso-abbrev): Dis. Markers
Journal ID (publisher-id): DM
Publisher: IOS Press
Copyright © 2012 Hindawi Publishing Corporation.
Received Day: 22 Month: 10 Year: 2012
Accepted Day: 22 Month: 10 Year: 2012
Print publication date: Year: 2012
Electronic publication date: Day: 5 Month: 12 Year: 2012
Volume: 33 Issue: 6
First Page: 313 Last Page: 320
PubMed Id: 23089926
Article Id: 673452
|Association of the Hindiii and S447X Polymorphisms in Lpl Gene with Hypertension and Type 2 Diabetes in Mexican Families|
|Iris Paola Guzmán-Guzmán1|
|José Francisco Muñoz-Valle2|
|Aralia Berenice Salgado-Bernabé1|
1Unidad Académica de Ciencias Químico BiológicasUniversidad Autónoma de GuerreroAvenida Lázaro Cárdenas S/NCiudad UniversitariaChilpancingoGuerreroMéxico
2Grupo de Inmunogenética Funcional (IIO)Departamento de Biología Molecular y GenómicaCUCSUniversidad de GuadalajaraJuan Díaz Covarrubias y Salvador Quevedo y ZubietaGuadalajaraJaliscoMéxico
|Correspondence: *Isela Parra-Rojas: email@example.com
Keywords: Lipoprotein lipase, polymorphisms, obesity, hypertension, type 2 diabetes.
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