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Association of the HindIII and S447X polymorphisms in LPL gene with hypertension and type 2 diabetes in Mexican families.
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MedLine Citation:
PMID:  23089926     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Lipoprotein lipase (LPL) is a key enzyme in lipid metabolism and is associated with obesity, dyslipidemias, hypertension (HTN) and type 2 diabetes mellitus (T2DM). LPL gene polymorphisms can be related with the development of cardiovascular risk factors. The present study was conducted to analyze the relationship of the HindIII and S447X polymorphisms in LPL gene with cardiovascular risk factors in Mexican families. The study population comprised ninety members of 30 Mexican families, in which an index case had obesity, were included in the study. We evaluated the body composition by bioelectrical impedance. Peripheral blood samples were collected to determine biochemical parameters. Screening for both polymorphisms was made by PCR-RFLPs. In the parents, both polymorphisms were in Hardy-Weinberg's equilibrium. We found that the genotype T/T of HindIII was associated with diastolic blood pressure ≥ 85 mmHg (OR=1.1; p=0.011), whereas the genotype C/C of S447X was associated with systolic blood pressure ≥ 130 mmHg (OR=1.2; p<0.001), diastolic blood pressure ≥ 85 mmHg (OR = 1.3; p< 0.001), T2DM (OR=1.3; p< 0.001) and with increase of total cholesterol (β =23.6 mg/mL; p=0.03). These data suggest that the HindIII and S447X LPL gene polymorphisms can confer susceptibility for the development of hypertension and T2DM in Mexican families.
Authors:
Salvador Muñoz-Barrios; Iris Paola Guzmán-Guzmán; José Francisco Muñoz-Valle; Aralia Berenice Salgado-Bernabé; Lorenzo Salgado-Goytia; Isela Parra-Rojas
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Disease markers     Volume:  33     ISSN:  1875-8630     ISO Abbreviation:  Dis. Markers     Publication Date:  2012  
Date Detail:
Created Date:  2012-12-11     Completed Date:  2013-05-20     Revised Date:  2013-12-11    
Medline Journal Info:
Nlm Unique ID:  8604127     Medline TA:  Dis Markers     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  313-20     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Blood Pressure / genetics
Body Mass Index
Cholesterol / blood
Diabetes Mellitus, Type 2 / genetics*
Female
Genetic Association Studies
Genetic Predisposition to Disease*
Humans
Hypertension / genetics*
Lipoprotein Lipase / genetics*
Male
Mexico
Middle Aged
Pedigree
Polymorphism, Restriction Fragment Length*
Polymorphism, Single Nucleotide*
Chemical
Reg. No./Substance:
97C5T2UQ7J/Cholesterol; EC 3.1.1.34/LPL protein, human; EC 3.1.1.34/Lipoprotein Lipase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): Dis Markers
Journal ID (iso-abbrev): Dis. Markers
Journal ID (publisher-id): DM
ISSN: 0278-0240
ISSN: 1875-8630
Publisher: IOS Press
Article Information
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Copyright © 2012 Hindawi Publishing Corporation.
Received Day: 22 Month: 10 Year: 2012
Accepted Day: 22 Month: 10 Year: 2012
Print publication date: Year: 2012
Electronic publication date: Day: 5 Month: 12 Year: 2012
Volume: 33 Issue: 6
First Page: 313 Last Page: 320
PubMed Id: 23089926
ID: 3810718
Article Id: 673452
DOI: 10.3233/DMA-2012-00940

Association of the Hindiii and S447X Polymorphisms in Lpl Gene with Hypertension and Type 2 Diabetes in Mexican Families
Salvador Muñoz-Barrios12
Iris Paola Guzmán-Guzmán1
José Francisco Muñoz-Valle2
Aralia Berenice Salgado-Bernabé1
Lorenzo Salgado-Goytia1
Isela Parra-Rojas1*
1Unidad Académica de Ciencias Químico BiológicasUniversidad Autónoma de GuerreroAvenida Lázaro Cárdenas S/NCiudad UniversitariaChilpancingoGuerreroMéxico
2Grupo de Inmunogenética Funcional (IIO)Departamento de Biología Molecular y GenómicaCUCSUniversidad de GuadalajaraJuan Díaz Covarrubias y Salvador Quevedo y ZubietaGuadalajaraJaliscoMéxico
Correspondence: *Isela Parra-Rojas: iprojas@yahoo.com


Article Categories:
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Keywords: Lipoprotein lipase, polymorphisms, obesity, hypertension, type 2 diabetes.

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