| Association of high-density lipoprotein cholesterol with coronary heart disease risk across categories of low-density lipoprotein cholesterol: the atherosclerosis risk in communities study. | |
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MedLine Citation:
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PMID: 21042169 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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INTRODUCTION: : National cholesterol treatment guidelines include a low level of high-density lipoprotein (HDL) cholesterol (<40 mg/dL) as a major risk factor for coronary heart disease (CHD) that should be considered when making decisions on treatment of low-density lipoprotein (LDL) cholesterol. METHODS: : We investigated the association of HDL and LDL-cholesterol with incident CHD events (fatal or nonfatal CHD) over 14 years of follow-up among 13,615 adults aged 45 to 64 years in the Atherosclerosis Risk in Communities study. RESULTS: : A total of 966 (7.1%) participants had a CHD event during follow-up. After adjustment for age, race, sex, diabetes, smoking, alcohol consumption, systolic blood pressure, waist circumference, chronic kidney disease and physical activity, a graded association was present between progressively lower levels of HDL-cholesterol and higher CHD risk, overall (P < 0.001) and within each level of LDL-cholesterol (<100, 100-129, 130-159, 160-189 and ≥190 mg/dL) investigated (all P < 0.05). In addition, after multivariable adjustment including LDL-cholesterol, each standard deviation higher HDL-cholesterol (18 mg/dL) was associated with a hazard ratio of incident CHD of 0.70 (95% CI: 0.63-0.77). CONCLUSIONS: : These data suggest a graded association exists between lower levels of HDL-cholesterol and CHD across the full range of LDL-cholesterol levels. As interventions targeting HDL levels are developed, the combinatorial effects of lower HDL levels with various levels of LDL-cholesterol should be examined. |
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Authors:
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Paul Muntner; Fleur Lee; Brad C Astor |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The American journal of the medical sciences Volume: 341 ISSN: 1538-2990 ISO Abbreviation: Am. J. Med. Sci. Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-02-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370506 Medline TA: Am J Med Sci Country: United States |
Other Details:
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Languages: eng Pagination: 173-80 Citation Subset: AIM; IM |
Affiliation:
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From the Department of Epidemiology (pm), Ryals School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama; Division of Nephrology (pm), Department of Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama; Pfizer Incorporated (fl), New York, New York; and Department of Epidemiology (bca), Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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