| Association of Helicobacter pylori and gastric autoimmunity: a population-based study. | |
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MedLine Citation:
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PMID: 7599605 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Based on clinical studies, a negative association between Helicobacter pylori and autoimmune corpus gastritis is described. In the present investigation of an unselected population of 1461 adults we can state, however, that there exists a relationship between H. pylori infection and the development of gastric corpus autoimmunity. As confirmation for the gastric autoantibody development through molecular mimicry, a high homology (72% in 25 amino acid overlap) between the beta subunit of H. pylori urease and that of H + K + ATPase, the gastric parietal cell autoantigen, was revealed. |
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Authors:
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R Uibo; T Vorobjova; K Metsküla; K Kisand; T Wadström; T Kivik |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: FEMS immunology and medical microbiology Volume: 11 ISSN: 0928-8244 ISO Abbreviation: FEMS Immunol. Med. Microbiol. Publication Date: 1995 Mar |
Date Detail:
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Created Date: 1995-08-10 Completed Date: 1995-08-10 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9315554 Medline TA: FEMS Immunol Med Microbiol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 65-8 Citation Subset: IM |
Affiliation:
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Institute of General and Molecular Pathology, University of Tartu, Estonia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Amino Acid Sequence Animals Antigens, Bacterial / genetics Autoantibodies / blood Autoantigens / genetics Autoimmune Diseases / microbiology* Cohort Studies Estonia Female Gastritis / immunology, microbiology* H(+)-K(+)-Exchanging ATPase / genetics Helicobacter Infections / immunology* Humans Immunoglobulin G / blood Male Mice Middle Aged Molecular Sequence Data Parietal Cells, Gastric / enzymology, immunology Rats Sequence Homology, Amino Acid Urease / genetics |
| Chemical | |
Reg. No./Substance:
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0/Antigens, Bacterial; 0/Autoantibodies; 0/Autoantigens; 0/Immunoglobulin G; EC 3.5.1.5/Urease; EC 3.6.1.10/H(+)-K(+)-Exchanging ATPase |
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