Document Detail

Association of Helicobacter pylori and gastric autoimmunity: a population-based study.
MedLine Citation:
PMID:  7599605     Owner:  NLM     Status:  MEDLINE    
Based on clinical studies, a negative association between Helicobacter pylori and autoimmune corpus gastritis is described. In the present investigation of an unselected population of 1461 adults we can state, however, that there exists a relationship between H. pylori infection and the development of gastric corpus autoimmunity. As confirmation for the gastric autoantibody development through molecular mimicry, a high homology (72% in 25 amino acid overlap) between the beta subunit of H. pylori urease and that of H + K + ATPase, the gastric parietal cell autoantigen, was revealed.
R Uibo; T Vorobjova; K Metsküla; K Kisand; T Wadström; T Kivik
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  FEMS immunology and medical microbiology     Volume:  11     ISSN:  0928-8244     ISO Abbreviation:  FEMS Immunol. Med. Microbiol.     Publication Date:  1995 Mar 
Date Detail:
Created Date:  1995-08-10     Completed Date:  1995-08-10     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  9315554     Medline TA:  FEMS Immunol Med Microbiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  65-8     Citation Subset:  IM    
Institute of General and Molecular Pathology, University of Tartu, Estonia.
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MeSH Terms
Amino Acid Sequence
Antigens, Bacterial / genetics
Autoantibodies / blood
Autoantigens / genetics
Autoimmune Diseases / microbiology*
Cohort Studies
Gastritis / immunology,  microbiology*
H(+)-K(+)-Exchanging ATPase / genetics
Helicobacter Infections / immunology*
Immunoglobulin G / blood
Middle Aged
Molecular Sequence Data
Parietal Cells, Gastric / enzymology,  immunology
Sequence Homology, Amino Acid
Urease / genetics
Reg. No./Substance:
0/Antigens, Bacterial; 0/Autoantibodies; 0/Autoantigens; 0/Immunoglobulin G; EC; EC ATPase

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