| Association of Health Aging and Body Composition (ABC) Heart Failure score with cardiac structural and functional abnormalities in young individuals. | |
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MedLine Citation:
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PMID: 20435191 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The Health ABC Heart Failure score has recently been shown to predict 5-year risk of incident heart failure in the elderly. We tested whether this risk score is associated with subclinical phenotypes of heart failure in a younger population. METHODS: We stratified participants in the Dallas Heart Study aged 30 to 65 years who had a cardiac magnetic resonance imaging and no self-reported history of heart failure or cardiomyopathy into 4 previously defined Health ABC Heart Failure risk groups: low (<5%), average (5%-10%), high (10%-20%), and very high (>20% risk for heart failure within 5 years). We compared left ventricular (LV) structural and functional parameters and levels of B-type natriuretic peptide (BNP) and N-terminal proBNP among the 4 groups. RESULTS: In the study cohort (N = 2,540), the percentage of subjects in the low-, average-, high-, and very high risk groups was 78%, 15%, 6%, and 1%, respectively. Indexed LV mass (80 +/- 15 vs 90 +/- 20 vs 95 +/- 25 vs 116 +/- 41 g/m(2)), concentricity (1.6 +/- 0.3 vs 1.8 +/- 0.4 vs 2.0 +/- 0.5 vs 2.2 +/- 0.7 g/mL), median BNP (2.8 vs 3.7 vs 4.9 vs 7.5 pg/mL) and N-terminal proBNP (26 vs 30 vs 40 vs 58 pg/mL), and prevalent LV systolic dysfunction and LV hypertrophy progressively increased across risk groups (P < .001 for all) independent of gender or method of indexing LV mass. CONCLUSIONS: The Health ABC Heart Failure score was associated with subclinical cardiac structural changes in the general population 30 to 65 years of age, suggesting that it may be a valid tool for identification of young individuals at increased risk for heart failure. |
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Authors:
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Sachin Gupta; Jarett D Berry; Colby R Ayers; Susan A Matulevicius; Ronald M Peshock; Parag C Patel; David W Markham; Mark H Drazner |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American heart journal Volume: 159 ISSN: 1097-6744 ISO Abbreviation: Am. Heart J. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-05-03 Completed Date: 2010-05-24 Revised Date: 2012-01-19 |
Medline Journal Info:
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Nlm Unique ID: 0370465 Medline TA: Am Heart J Country: United States |
Other Details:
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Languages: eng Pagination: 817-24 Citation Subset: AIM; IM |
Copyright Information:
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2010 Mosby, Inc. All rights reserved. |
Affiliation:
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Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, 75390-9047, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult African Americans / statistics & numerical data Aged Body Composition Cross-Sectional Studies Female Health Status Indicators* Heart Failure / epidemiology Humans Hypertrophy, Left Ventricular / epidemiology Magnetic Resonance Imaging Male Middle Aged Natriuretic Peptide, Brain / blood Prognosis Risk Assessment Sex Factors Ventricular Dysfunction, Left / blood, epidemiology* Ventricular Function, Left |
| Grant Support | |
ID/Acronym/Agency:
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K23 HL092229-03/HL/NHLBI NIH HHS; K23 HL092229-04/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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114471-18-0/Natriuretic Peptide, Brain |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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