| Association of HLA antigens, toxic reactions and therapeutic response to auranofin and aurothioglucose in patients with rheumatoid arthritis. | |
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MedLine Citation:
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PMID: 6415865 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To investigate the possible relation between HLA antigens and either favourable clinical response or toxic reaction to two different gold compounds, aurothioglucose and auranofin, a new orally absorbable gold compound, we studied 50 patients with rheumatoid arthritis prospectively. Of the 25 aurothioglucose-treated patients, response to treatment could not be evaluated in four patients because of early toxicity. Nine patients showed an excellent response, while 12 were moderate or non-responders. Four of the 9 excellent responders were HLA-DR3 positive, but none of the 12 moderate or non-responders possessed this antigen (P less than 0.025). In accordance with previous reports HLA-DR3 was found more frequently in patients developing toxicity on aurothioglucose than in those who did not (RR = 5.6). No association was found between HLA antigens and favourable clinical response in 25 auranofin-treated patients. Two of them showed a severe adverse reaction, neither of them being DR3-positive. HLA-DR3 positivity is associated not only with drug toxicity, but also with excellent respondership to aurothioglucose treatment. |
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Authors:
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P L van Riel; P Reekers; L B van de Putte; F W Gribnau |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Tissue antigens Volume: 22 ISSN: 0001-2815 ISO Abbreviation: Tissue Antigens Publication Date: 1983 Sep |
Date Detail:
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Created Date: 1983-12-20 Completed Date: 1983-12-20 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0331072 Medline TA: Tissue Antigens Country: DENMARK |
Other Details:
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Languages: eng Pagination: 194-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Arthritis, Rheumatoid
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drug therapy,
genetics* Aurothioglucose / adverse effects, therapeutic use Dose-Response Relationship, Drug HLA Antigens / genetics* Humans |
| Chemical | |
Reg. No./Substance:
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0/HLA Antigens; 12192-57-3/Aurothioglucose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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