| Association of HLA-DRw2 antigen with presumed ocular histoplasmosis. | |
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MedLine Citation:
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PMID: 7356790 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Patients with presumed ocular histoplasmosis syndrome were typed for HLA-A, B, C, and DR antigens. It was found that 21 (81%) of 26 of the presumed ocular histoplasmosis syndrome patients with disciform macular scarring and 8 (62%) of 13 of the presumed ocular histoplasmosis syndrome patients with peripheral atrophic spots typed for DRw2. The frequency of DRw2 in normal blood donors was 28%. The 77% (20 patients) frequency of B7 in 26 of the presumed ocular histoplasmosis syndrome patients with disciform scarring was also significantly higher than the 25.6% frequency of B7 in normal blood donors. In contrast, no significant differences were observed in any HLA antigen frequency for patients with disciform scarring of degenerative choroidopathy. These observations suggest that an association with DRw2 may play a role in the pathogenesis of the eye lesions after Histoplasma capsulatum infection. |
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Authors:
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T A Meredith; R E Smith; R J Duquesnoy |
Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: American journal of ophthalmology Volume: 89 ISSN: 0002-9394 ISO Abbreviation: Am. J. Ophthalmol. Publication Date: 1980 Jan |
Date Detail:
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Created Date: 1980-03-24 Completed Date: 1980-03-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370500 Medline TA: Am J Ophthalmol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 70-6 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Choroid
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pathology Eye Diseases / etiology, immunology*, pathology HLA Antigens / analysis* Histoplasmosis / complications, immunology*, pathology Humans Macula Lutea / pathology Syndrome |
| Chemical | |
Reg. No./Substance:
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0/HLA Antigens |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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