Document Detail

Association of HLA-Bw46DR9 combination with juvenile myasthenia gravis in Chinese.
MedLine Citation:
PMID:  8482958     Owner:  NLM     Status:  MEDLINE    
One hundred and fifty two Chinese patients with myasthenia gravis in Taiwan were investigated for HLA-A, B, C and DR/DQ typing. HLA-Bw46 and DR9 frequencies were significantly increased in patients compared with the control group, and there was a decrease in DR3. Further analysis between different subgroups of patients showed Bw46 and DR9 were more significantly increased in the juvenile group than in the adult group. No single HLA allele was associated with either clinical type or thymic pathology, but there was an excess of BW46DR9 combination in both juvenile and ocular type patients. The Chinese population with myasthenia gravis is characterised by earlier age at onset, more ocular forms and less clinically severe illness than in whites, and these characteristics indicate a special subgroup that correlates with the strong Bw46DR9 association.
W H Chen; H C Chiu; R P Hseih
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neurology, neurosurgery, and psychiatry     Volume:  56     ISSN:  0022-3050     ISO Abbreviation:  J. Neurol. Neurosurg. Psychiatr.     Publication Date:  1993 Apr 
Date Detail:
Created Date:  1993-06-03     Completed Date:  1993-06-03     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985191R     Medline TA:  J Neurol Neurosurg Psychiatry     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  382-5     Citation Subset:  IM    
Shin Kong WHS Memorial Hospital, Taipei, Taiwan, ROC.
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MeSH Terms
Child, Preschool
Ethnic Groups / genetics*
Gene Frequency / genetics
HLA-A2 Antigen / genetics
HLA-B Antigens / genetics*
HLA-C Antigens / genetics
HLA-DR Antigens / genetics*
Middle Aged
Myasthenia Gravis / genetics*
Reg. No./Substance:
0/HLA-A2 Antigen; 0/HLA-B Antigens; 0/HLA-Bw46; 0/HLA-C Antigens; 0/HLA-Cw1; 0/HLA-DR Antigens; 0/HLA-DR9

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