| Association of Glucocorticoid Receptor Polymorphism A3669G with decreased risk of developing diabetes in patients with Cushing's Syndrome. | |
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MedLine Citation:
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PMID: 22048965 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Objective: Glucocorticoid receptor (GR) polymorphisms alter glucocorticoid sensitivity and have been associated with altered metabolic profiles. We evaluate the prevalence of the four GR polymorphisms BclI, N363S, ER22/23EK and A3669G in patients with Cushing's Syndrome (CS) compared to healthy controls (HC) and we investigate their role in the development of metabolic abnormalities in patients with CS according to their hormonal profile.Patients and Methods: Sixty-one patients with CS and 71 sex and age matched HC were genotyped.Results: BclI variant was markedly higher in patients with CS when compared to healthy controls (62 vs. 41%, p <0.05) while no significant differences were found among others polymorphisms. A very low frequency of N363S and the ER22/23EK was observed.In CS patients, despite the significantly increased levels of serum morning cortisol in BclI carriers compared to wild-type no clinical or metabolic differences were found.In contrast, A3669G GR carriers showed a significantly reduced prevalence of type 2 diabetes mellitus compared with wild-type (19 vs. 68%, p =0.001) despite the higher levels of both serum morning (21.7 ± 6 vs. 27.3 ± 8.6 mcg/dl, p =0.009) and midnight cortisol (18.8 ± 5.8 vs. 24.0 ± 8.0 mcg/dl, p =0.01). The negative association between diabetes and A3669G GR polymorphism remained significant when data were adjusted for potential confounding factors.Conclusions: The A3669G polymorphism of the GR gene plays a protective role in patients with CS, attenuating the effects of glucocorticoid excess on glucose metabolism as shown by their reduced risk of diabetes. |
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Authors:
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Laura Trementino; Gloria Appolloni; Carolina Concettoni; Marina Cardinaletti; Marco Boscaro; Giorgio Arnaldi |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-2 |
Journal Detail:
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Title: European journal of endocrinology / European Federation of Endocrine Societies Volume: - ISSN: 1479-683X ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-3 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9423848 Medline TA: Eur J Endocrinol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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L Trementino, Clinica di Endocrinologia, Università Politecnica Marche, Ancona, 60020, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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