Document Detail


Association of the Gln27Glu polymorphism of the beta-2-adrenergic receptor with preterm labor.
MedLine Citation:
PMID:  12065131     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To investigate a potential association between the beta-2-adrenergic receptor (B2AR) polymorphisms occurring at amino acid positions 16 (Arg16Gly) and 27 (Gln27Glu) and preterm labor. METHODS: Eighty patients with preterm labor and 76 control subjects were analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). RESULTS: A significant association was found between Gln27Glu substitution and preterm labor (P=0.001). The frequency of Gly16 and Glu27 alleles were found to be higher in patients than in control women (0.54 vs. 0.48 and 0.42 vs. 0.26, respectively), and the odds ratio for the occurrence of preterm labor was 2.14 (95% CI, 1.32-3.46; P=0.002) for the Glu 27 allele. An early delivery was noted in 52.5% of patients. CONCLUSION: The Gln27Glu polymorphism of the B2AR gene may have a role in molecular pathogenesis of preterm labor. Glu27 allele in patients with preterm labor might be a risk factor for deliveries before 37 weeks of gestation.
Authors:
M Ozkur; F Dogulu; A Ozkur; B Gokmen; S S Inaloz; A S Aynacioglu
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics     Volume:  77     ISSN:  0020-7292     ISO Abbreviation:  Int J Gynaecol Obstet     Publication Date:  2002 Jun 
Date Detail:
Created Date:  2002-06-14     Completed Date:  2002-09-03     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0210174     Medline TA:  Int J Gynaecol Obstet     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  209-15     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, Medical Faculty, Gaziantep University, Turkey. aozkur@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Alleles
Female
Gestational Age
Humans
Obstetric Labor, Premature / genetics*
Odds Ratio
Polymerase Chain Reaction
Polymorphism, Genetic*
Polymorphism, Restriction Fragment Length
Pregnancy
Receptors, Adrenergic, beta-2 / genetics*
Risk Factors
Chemical
Reg. No./Substance:
0/Receptors, Adrenergic, beta-2

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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