Document Detail


Association of GSTP1 Ile105Val polymorphism and risk of head and neck cancers: a meta-analysis of 28 case-control studies.
MedLine Citation:
PMID:  23144854     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND AIMS: The Glutathione S-transferase P1 (GSTP1) polymorphism have been considered a risk modifier for developing head and neck cancer (HNC) in many studies; however, the results of such studies are inconsistent. The aim of this study was to evaluate the possible association between the GSTP1 Ile105Val polymorphism and risk of HNC.
METHOD: We performed a search in the relevant electronic database and a meta-analysis based on 28 published case-control studies that included 6,404 cases and 6,523 controls. To take into account the possibility of heterogeneity across the studies, a Chi-square based I(2)-statistic test was performed. Crude pooled odds ratios (ORs) with 95% confidence intervals (CIs) were assessed using both fixed-effects and random-effects models.
RESULTS: The results of this meta-analysis showed that the GSTP1 Ile105Val polymorphism was not significantly associated with risk of HNC in the overall study population (pooled OR 1.00, 95% CI 0.92-1.09) or in subgroup analyses stratified by ethnicity, sample size, tumor site or publication year. Moreover, substantial evidence of heterogeneity among the studies was observed. Publication year was identified as the main cause of heterogeneity.
CONCLUSION: This meta-analysis does not support a significant association between the GSTP1 Ile105Val polymorphism and risk of HNC.
Authors:
Juntian Lang; Xicheng Song; Jinwei Cheng; Shuwei Zhao; Jingping Fan
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Publication Detail:
Type:  Journal Article; Meta-Analysis; Review     Date:  2012-11-07
Journal Detail:
Title:  PloS one     Volume:  7     ISSN:  1932-6203     ISO Abbreviation:  PLoS ONE     Publication Date:  2012  
Date Detail:
Created Date:  2012-11-12     Completed Date:  2013-04-25     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  101285081     Medline TA:  PLoS One     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e48132     Citation Subset:  IM    
Affiliation:
Department of Otorhinolaryngology-Head & Neck Surgery, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, China.
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MeSH Terms
Descriptor/Qualifier:
Case-Control Studies
Gene Frequency
Genetic Association Studies
Genetic Predisposition to Disease
Glutathione S-Transferase pi / genetics*
Head and Neck Neoplasms / genetics*
Humans
Mutation, Missense*
Polymorphism, Genetic
Publication Bias
Regression Analysis
Chemical
Reg. No./Substance:
EC 2.5.1.18/GSTP1 protein, human; EC 2.5.1.18/Glutathione S-Transferase pi
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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