Document Detail

Association of Fas-670 gene polymorphism with risk of cervical cancer in North Indian population.
MedLine Citation:
PMID:  18754288     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Cervical cancer is the second most common cancer among women in the world, with approximately 470,000 new cases and 231,000 deaths occurring each year. Incidence is greater in developing countries such as India, where this is the most common female malignancy with almost 100,000 new cases each year. Apoptosis must be considered as a safe mechanism that controls the integrity of the cell erasing abnormal clones and it is likely that failure of apoptosis constitutes a key factor responsible for tumor formation, progression and resistance to drugs. The Fas gene plays a key role in regulation of apoptotic cell death and corruption of this signaling pathway has been shown to participate in immune escape and tumorgenesis. STUDY DESIGN: A single-nucleotide polymorphism at -670 of Fas gene promoter (A/G) was examined in a total of 400 blood samples from normal healthy women and cervical cancer patients, using polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) technique. RESULTS: Significant association was observed for AG (OR = 3.0, 95% CI = (1.68-5.09, p < 0.001) and combined AG+GG (OR = 2.54, 95% CI = 1.47-4.40, p < 0.001) genotype with risk of cervical cancer. Heterozygous genotype (AG) in SCC showed a highly significant association with risk of cervical cancer (OR = 2.57, 95% CI = 1.47-4.50 p <0.001). Similarly, combined AG+GG genotype had a 2.25-fold risk for SCC patients (OR = 2.25, 95% CI = 1.30-3.90, p < 0.001). There was high increase risk of cervical cancer in passive smokers with AG and combined (AG+GG) genotypes (OR = 4.6, 95% CI = 2.07-10.32, p < 0.001 - OR = 4.9, 95% CI = 2.20-10.32, p < 0.001), respectively. CONCLUSION: This is the first study to provide evidence for the association of a Fas -670 (A/G) gene polymorphism with the risk of cervical cancer in a North Indian population.
D M Kordi Tamandani; R C Sobti; M Shekari
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and experimental obstetrics & gynecology     Volume:  35     ISSN:  0390-6663     ISO Abbreviation:  Clin Exp Obstet Gynecol     Publication Date:  2008  
Date Detail:
Created Date:  2008-08-29     Completed Date:  2008-11-04     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7802110     Medline TA:  Clin Exp Obstet Gynecol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  183-6     Citation Subset:  IM    
Department of Biotechnology, Panjab University, Chandigrah, India.
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MeSH Terms
Antigens, CD95 / genetics*
Asian Continental Ancestry Group
Case-Control Studies
Genetic Predisposition to Disease / genetics*
Middle Aged
Odds Ratio
Polymorphism, Single Nucleotide / genetics*
Promoter Regions, Genetic / genetics*
Tobacco Smoke Pollution
Uterine Cervical Neoplasms / genetics*
Reg. No./Substance:
0/Antigens, CD95; 0/Tobacco Smoke Pollution

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