| The association of dipyridamole side effects with hemodynamic parameters, ECG findings, and scintigraphy outcomes. | |
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MedLine Citation:
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PMID: 20724532 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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METHODS: Overall, 590 patients referred to the nuclear medicine center for myocardial perfusion imaging were evaluated for adverse dipyridamole effects concurrent with a low level of exercise. Before and during dipyridamole infusion, the patients' vital signs, electrocardiogram, heart rate, systolic blood pressure, and diastolic blood pressure were monitored; all patients underwent stress-rest (99m)Tc-sestamibi gated SPECT using a 2-d protocol. RESULTS: Eighty-eight patients (14.9%) experienced at least one side effect during dipyridamole infusion, and abnormal ECG and scan results were observed in 32.4% and 48.6% of patients, respectively. We observed a positive correlation between a higher incidence of chest discomfort, headache, and dyspnea and abnormalities on ECG and myocardial perfusion imaging. In addition, these 3 side effects were also associated with a higher postinfusion heart rate, lower preinfusion systolic blood pressure, and lower postinfusion diastolic blood pressure. There were significant differences between pre- and postinfusion heart rate, preinfusion systolic blood pressure, and postinfusion diastolic blood pressure among patients with or without side effects, whereas no significant difference was observed in any of the hemodynamic parameters between patients with normal and abnormal ECG results or myocardial perfusion imaging results. CONCLUSION: This study demonstrated a correlation between hemodynamic variables and side effects but not with imaging findings or ECG findings. |
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Authors:
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Hamid Javadi; Malihnaz Shariati; Mehdi Mogharrabi; Isa Neshandar Asli; Sara Jallalat; Aref Hooman; Mohammad Seyedabadi; Majid Assadi |
Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't Date: 2010-08-19 |
Journal Detail:
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Title: Journal of nuclear medicine technology Volume: 38 ISSN: 1535-5675 ISO Abbreviation: J Nucl Med Technol Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-02 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0430303 Medline TA: J Nucl Med Technol Country: United States |
Other Details:
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Languages: eng Pagination: 149-52 Citation Subset: IM |
Affiliation:
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Department of Nuclear Medicine, 5th Azar Hospital, Golestan University of Medical Science, Gorgan, Iran. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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