Document Detail


Association of Connexin37 C1019T with myocardial infarction and coronary artery disease: a meta-analysis.
MedLine Citation:
PMID:  24937033     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: Several studies have reported that Connexin37 (Cx37) gene C1019T polymorphism is associated with myocardial infarction (MI) and coronary artery disease (CAD). However, the results remain contradictory.
METHODS AND RESULTS: Pubmed, Embase, and Cochrane library databases were systemically searched. Data were extracted by two independent reviewers and pooled odds ratio (OR) with 95% confidence interval (CI) were calculated. A total of 3498 MI cases and 3986 controls, as well as 1808 CAD cases and 1197 controls were enrolled in this meta-analysis. For MI, the overall ORs and 95% CIs of 1019T were 1.04, 0.95-1.15; and 1.02, 0.85-1.22 in dominant and recessive models, respectively. For CAD, the overall ORs and 95% CIs of 1019T were 0.61, 0.51-0.72; and 0.52, 0.43-0.62 in dominant and recessive models, respectively. No publication bias was found in this meta-analysis.
CONCLUSIONS: This meta-analysis showed that Cx37 C1019T is a risk factor for MI and a protective factor for CAD.
Authors:
Dan Wen; Xin Du; Shao-Ping Nie; Jian-Zeng Dong; Chang-Sheng Ma
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Publication Detail:
Type:  REVIEW     Date:  2014-6-14
Journal Detail:
Title:  Experimental gerontology     Volume:  -     ISSN:  1873-6815     ISO Abbreviation:  Exp. Gerontol.     Publication Date:  2014 Jun 
Date Detail:
Created Date:  2014-6-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0047061     Medline TA:  Exp Gerontol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014. Published by Elsevier Inc.
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